Imidazo(1,2-a)pyridine-3-acetamide, 2-(p-chlorophenyl)-

Base Information

• Chemical Name: Imidazo(1,2-a)pyridine-3-acetamide, 2-(p-chlorophenyl)-
• CAS No.: 21801-83-2
• Molecular Formula: C15H12 Cl N3 O
• Molecular Weight: 285.73
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40176218
• Nikkaji Number: J40.934K
• Wikidata: Q83046540
• Mol file: 21801-83-2.mol

Synonyms:21801-83-2;Imidazo(1,2-a)pyridine-3-acetamide, 2-(p-chlorophenyl)-;BRN 0808275;DTXSID40176218;3-(Carbamoylmethyl)-2-(p-chlorophenyl)imidazo(1,2-a)pyridine;Imidazo(1,2-a)pyridine, 3-(carbamoylmethyl)-2-(p-chlorophenyl)-

Chemical Property of Imidazo(1,2-a)pyridine-3-acetamide, 2-(p-chlorophenyl)-

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 15.39±0.40(Predicted)
• Flash Point: °C
• PSA: 61.38000
• Density: 1.37g/cm³
• LogP: 3.83220
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 285.0668897
• Heavy Atom Count: 20
• Complexity: 357

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC(=C(N2C=C1)CC(=O)N)C3=CC=C(C=C3)Cl

Technology Process of Imidazo(1,2-a)pyridine-3-acetamide, 2-(p-chlorophenyl)-

There total 3 articles about Imidazo(1,2-a)pyridine-3-acetamide, 2-(p-chlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium cyanide (151-50-8) + 1-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine (338415-39-7) → 2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetonitrile (17744-99-9) + 2-[2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide (21801-83-2)

Guidance literature:

1-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine; With methyl iodide; In dichloromethane; at 20 ℃; for 24h;

potassium cyanide; In water; for 4h; Heating;

Reference yield:

2-(4-chlorophenyl)imidazolo[1,2-a]pyridine (38922-74-6) → 2-[2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide (21801-83-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 85 percent / acetic acid / H₂O / 4 h / 50 - 55 °C

2.1: MeI / CH₂Cl₂ / 24 h / 20 °C

2.2: H₂O / 4 h / Heating

With acetic acid; methyl iodide; In dichloromethane; water;

Reference yield:

→ 2-[2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide (21801-83-2)

Guidance literature:

2-(4-Chlor-phenyl)-3-cyanmethyl-imidazo<1.2-a>pyridin, H2SO4; Ausb.: 84.5percent;

DOI:10.1021/jm00301a031

upstream raw materials:

potassium cyanide

1-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine

2-(4-chlorophenyl)imidazolo[1,2-a]pyridine

Downstream raw materials:

[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]acetic acid

2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylacetamide

Refernces