Octanoic acid, 2-hydroxy-, phenylmethyl ester

Base Information

• Chemical Name: Octanoic acid, 2-hydroxy-, phenylmethyl ester
• CAS No.: 95513-13-6
• Molecular Formula: C15H22O3
• Molecular Weight: 250.338
• Mol file: 95513-13-6.mol

Synonyms:

Chemical Property of Octanoic acid, 2-hydroxy-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Octanoic acid, 2-hydroxy-, phenylmethyl ester

There total 9 articles about Octanoic acid, 2-hydroxy-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-hydroxy-octanoic acid (617-73-2) + benzyl bromide (100-39-0) → benzyl 2-hydroxyoctanoate (95513-13-6)

Guidance literature:

With triethylamine; In ethyl acetate; for 7h; Heating;

DOI:10.1021/jo00208a016

Reference yield:

2-hydroxyoctanenitrile (66471-52-1) → benzyl 2-hydroxyoctanoate (95513-13-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 40percent H₂SO₄ / 3 h / 125 °C

2: 6 N NaOH

3: 83 percent / triethylamine / ethyl acetate / 7 h / Heating

With sodium hydroxide; sulfuric acid; triethylamine; In ethyl acetate;

DOI:10.1021/jo00208a016

Reference yield:

2-hydroxy-octanoic acid amide (28870-09-9) → benzyl 2-hydroxyoctanoate (95513-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 6 N NaOH

2: 83 percent / triethylamine / ethyl acetate / 7 h / Heating

With sodium hydroxide; triethylamine; In ethyl acetate;

DOI:10.1021/jo00208a016

upstream raw materials:

2-hydroxy-octanoic acid

benzyl bromide

benzyl alcohol

octanoic acid ethyl ester

Downstream raw materials:

(2S)-cis-1-(phenylsulfonyl)-2-(1-<(phenylsulfonyl)oxy>butyl)-5-heptylpyrrolidine

(2S)-cis-1-benzyl-5-heptylproline tert-butyl ester

(2S)-trans-1-benzyl-5-heptylproline tert-butyl ester

(2S)-cis-5-butyl-2-heptyl-1-(phenylsulfonyl)pyrrolidine

Refernces

• 1、 -. "Acyl pseudodipeptides which carry a functionalised auxialiary arm". . . Retrieved 2008/06/13.
• 2、 Shiosaki, Kazumi,Rapoport, Henry. "α-Amino Acids as Chiral Educts for Asymmetric Products. Chirospecific Syntheses of the 5-Butyl-2-heptylpyrrolidines from Glutamic Acid". . p. 1229 - 1239. Retrieved 2007/10/02.