2-PYRIDIN-2-YL-1H-INDOLE

Base Information

• Chemical Name: 2-PYRIDIN-2-YL-1H-INDOLE
• CAS No.: 13228-40-5
• Molecular Formula: C13H10N2
• Molecular Weight: 194.236
• Hs Code.: 2933990090
• Mol file: 13228-40-5.mol

Synonyms:Indole,2-(2-pyridyl)- (6CI,7CI,8CI);2-(2-Pyridyl)indole;2-Pyridylindole;NSC 112668;

Chemical Property of 2-PYRIDIN-2-YL-1H-INDOLE

Chemical Property:

• Vapor Pressure: 1.58E-06mmHg at 25°C
• Melting Point: 152.0 to 156.0 °C
• Refractive Index: 1.688
• Boiling Point: 409.105 °C at 760 mmHg
• PKA: 15.65±0.30(Predicted)
• Flash Point: 186.626 °C
• PSA: 28.68000
• Density: 1.211 g/cm³
• LogP: 3.22990
• Storage Temp.: Sealed in dry,Room Temperature
• Sensitive.: Light Sensitive

Purity/Quality:

98%min ^*data from raw suppliers

2-(Pyrdin-2-yl)-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PYRIDIN-2-YL-1H-INDOLE

There total 5 articles about 2-PYRIDIN-2-YL-1H-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.9%

2-(o-nitrostyryl)pyridine (50385-24-5) → 2-(2-pyridin-2-yl-vinyl)-aniline (105376-41-8) + 2-(2-pyridinyl)-1H-indole (13228-40-5)

Guidance literature:

With carbon monoxide; dodecacarbonyl-triangulo-triruthenium; In toluene; at 220 ℃; for 5h; under 60800 Torr;

DOI:10.1039/c39860000784

Reference yield: 35.2%

carbon monoxide (201230-82-2) + 2-(o-nitrostyryl)pyridine (50385-24-5) → 2-(2-pyridin-2-yl-vinyl)-aniline (105376-41-8) + 2-(2-pyridinyl)-1H-indole (13228-40-5) + 3-(pyridin-2-yl)quinolin-2(1H)-one (71978-20-6)

Guidance literature:

hexarhodium hexadecacarbonyl; In toluene; at 220 ℃; for 5h; under 60800 Torr;

DOI:10.1039/c39860000784

Reference yield:

2-chloropyridine (109-09-1) + indole (120-72-9) → 2-(2-pyridinyl)-1H-indole (13228-40-5) + 5-(2-pyridyl)indole (117908-10-8) + 3-(pyridin-2-yl)-1H-indole (3139-24-0) + 6-(2-pyridyl)indole (117908-11-9)

Guidance literature:

In acetonitrile; for 12h; Further byproducts given; Irradiation;

upstream raw materials:

2-chloropyridine

indole

2-iodopyridine

2-(o-nitrostyryl)pyridine

Downstream raw materials:

2-(2'-pyridyl)3-<(N-ethan-2-ol-N-imidazolin-2'-ylamino)methyl>indole-hydroiodide

2-(2'-pyridyl)3-<(N-propan-3-ol-N-imidazolin-2'-ylamino)methyl>indole-hydroiodide

1-[(4,5-Dihydro-1H-imidazol-2-yl)-(2-pyridin-2-yl-1H-indol-3-ylmethyl)-amino]-butan-1-ol; hydriodide

1-phenylsulfonyl-2-(pyridin-2-yl)-1H-indole

Refernces

• 1、 Crotti, Corrado,Cenini, Sergio,Rindone, Bruno,Tollari, Stefano,Demartin, Francesco. "Deoxygenation Reactions of ortho-Nitrostyrenes with Carbon Monoxide Catalysed by Metal Carbonyls: a New Route to Indoles". . p. 784 - 786. Retrieved 2007/10/02.