8-AMINOGUANINE

Base Information

• Chemical Name: 8-AMINOGUANINE
• CAS No.: 28128-41-8
• Molecular Formula: C5H6N6O
• Molecular Weight: 166.142
• Hs Code.: 2933990090
• Mol file: 28128-41-8.mol

Synonyms:6H-Purin-6-one,2,8-diamino-1,7-dihydro- (9CI);Hypoxanthine, 2,8-diamino- (8CI);8-Aminoguanine;NSC 23170;Hydrazinecarboximidamide;

Chemical Property of 8-AMINOGUANINE

Chemical Property:

• Vapor Pressure: 7.59E-06mmHg at 25°C
• Melting Point: >330°C (dec.)
• Refractive Index: 2.228
• Boiling Point: 625.9 °C at 760 mmHg
• Flash Point: 332.3 °C
• PSA: 126.47000
• Density: 2.53 g/cm³
• LogP: -0.02700
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: Aqueous Base (Sparingly, Heated), DMSO (Very Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

8-Aminoguanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Aminoguanine accelerates DNA tetramolecular G-quadruplex formation.

Technology Process of 8-AMINOGUANINE

There total 7 articles about 8-AMINOGUANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

8-<(4-bromophenyl)azo>guanine (79953-02-9) → 8-aminoguanine (28128-41-8)

Guidance literature:

With sodium dithionite; In sodium hydroxide; at 90 ℃; for 48h; pH 9;

DOI:10.1021/jo00342a014

Reference yield:

2-amino-1,9-dihydro-6H-purin-6-one (73-40-5) → 8-aminoguanine (28128-41-8)

Guidance literature:

2-amino-1,9-dihydro-6H-purin-6-one; With 4-chlorophenyldiazonium salt;

With sodium hydrogensulfite;

DOI:10.1081/NCN-100002498

Reference yield:

8-aminoguanosine (3868-32-4) → 8-aminoguanine (28128-41-8)

Guidance literature:

With hydrogenchloride; In water; at 70 ℃; for 1h;

DOI:10.1021/tx990094u

upstream raw materials:

2,5-dichlorobenzenediazonium

guanine

8-<(4-bromophenyl)azo>guanine

8-nitroguanine

Refernces

• 1、 Chen, Hauh-Jyun Candy,Chen, Yuan-Mao,Wang, Tze-Fan,Wang, Kuang-Sian,Shiea, Jentaie. "8-Nitroxanthine, an adduct derived from 2′-deoxyguanosine or DNA reaction with nitryl chloride". . p. 536 - 546. Retrieved 2007/10/03.
• 2、 Janeba,Holy. "Synthesis of 8-amino and 8-substituted amino derivatives of acyclic purine nucleoside and nucleotide analogs. Alkylation of 8-substituted purine bases". . p. 1103 - 1106. Retrieved 2007/10/03.