Technology Process of L-Phenylalanine,
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-(4-methyl-5-oxo-2-thioxo-1-imid
azolidinyl)-, methyl ester
There total 9 articles about L-Phenylalanine,
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-(4-methyl-5-oxo-2-thioxo-1-imid
azolidinyl)-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / H2 / 10percent Pd-C / dioxane / 1 h / Ambient temperature
2: SOCl2
3: 79 percent / 1 M NaHCO3 / CHCl3; H2O / 2 h / Ambient temperature
4: 1.) Et3N / 1.) pyridine, dioxane, H2O, 40 deg C, 2 h; 2.) trifluoroacetic acid, Rt, 30 min
With
thionyl chloride; hydrogen; sodium hydrogencarbonate; triethylamine;
palladium on activated charcoal;
In
1,4-dioxane; chloroform; water;
DOI:10.1039/P29840001723
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / H2 / 10percent Pd-C / dioxane / 1 h / Ambient temperature
2: SOCl2
3: 79 percent / 1 M NaHCO3 / CHCl3; H2O / 2 h / Ambient temperature
4: 1.) NaHCO3 / 1.) pyridine, dioxan, H2O, Rt, 1 h; 2.) trifluoroacetic acid, Rt, 1 h
With
thionyl chloride; hydrogen; sodium hydrogencarbonate;
palladium on activated charcoal;
In
1,4-dioxane; chloroform; water;
DOI:10.1039/P29840001723
- Guidance literature:
-
Multi-step reaction with 3 steps
1: SOCl2
2: 79 percent / 1 M NaHCO3 / CHCl3; H2O / 2 h / Ambient temperature
3: 1.) Et3N / 1.) pyridine, dioxane, H2O, 40 deg C, 2 h; 2.) trifluoroacetic acid, Rt, 30 min
With
thionyl chloride; sodium hydrogencarbonate; triethylamine;
In
chloroform; water;
DOI:10.1039/P29840001723
