Methanone, (4-methylphenyl)-2-pyridinyl-, oxime

Base Information

• Chemical Name: Methanone, (4-methylphenyl)-2-pyridinyl-, oxime
• CAS No.: 95898-82-1
• Molecular Formula: C13H12N2O
• Molecular Weight: 212.251
• Mol file: 95898-82-1.mol

Synonyms:

Chemical Property of Methanone, (4-methylphenyl)-2-pyridinyl-, oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanone, (4-methylphenyl)-2-pyridinyl-, oxime

There total 1 articles about Methanone, (4-methylphenyl)-2-pyridinyl-, oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-toluoyl)pyridine (78539-88-5) → C13H12N2O (95898-82-1)

Guidance literature:

2-(4-toluoyl)pyridine; With hydroxylamine hydrochloride; In methanol; at 20 ℃; for 24h;

With sodium hydrogencarbonate; In water;

DOI:10.1021/jo900415y

Reference yield:

C13H12N2O (95898-82-1) → 1-(4-methylphenyl)-1-(2-pyridyl)methylamine (39930-13-7)

Guidance literature:

C₁₃H₁₂N₂O; With trifluoroacetic acid; zinc; at 20 ℃; for 48h;

With sodium hydroxide; water;

DOI:10.1021/jo900415y

Reference yield:

C13H12N2O (95898-82-1) → phenyl(1-(p-tolyl)imidazo[1,5-a]pyridin-3-yl)methanone

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; trifluoroacetic acid / 48.5 h / 20 °C

2: iodine; oxygen; hydrogenchloride / dimethyl sulfoxide / 24 h / 100 °C

With hydrogenchloride; iodine; oxygen; trifluoroacetic acid; zinc; In dimethyl sulfoxide;

DOI:10.1016/j.cclet.2021.05.018

upstream raw materials:

2-(4-toluoyl)pyridine

Downstream raw materials:

1-(4-methylphenyl)-1-(2-pyridyl)methylamine

Refernces

• 1、 Shibahara, Fumitoshi,Sugiura, Rie,Yamaguchi, Eiji,Kitagawa, Asumi,Murai, Toshiaki. "Synthesis of fluorescent 1,3-diarylated imidazo[1,5-α]pyridines: Oxidative condensation-cyclization of aryl-2-pyridylmethylamines and aldehydes with elemental sulfur as an oxidant". supporting information; experimental part. p. 3566 - 3568. Retrieved 2009/09/05.