(S)-Pyrrolidine-2-carboxamide monohydrochloride

Base Information

• Chemical Name: (S)-Pyrrolidine-2-carboxamide monohydrochloride
• CAS No.: 42429-27-6
• Molecular Formula: C5H10N2O^.HCl
• Molecular Weight: 150.608
• Hs Code.: 2933990090
• European Community (EC) Number: 255-818-2
• DSSTox Substance ID: DTXSID10195214
• Mol file: 42429-27-6.mol

Synonyms:42429-27-6;L-Prolinamide hydrochloride;(S)-Pyrrolidine-2-carboxamide hydrochloride;(2S)-pyrrolidine-2-carboxamide hydrochloride;L-Proline amide hydrochloride;L-Prolinamide HCl;(S)-Pyrrolidine-2-carboxamide monohydrochloride;L-Prolinamide, HCl;(S)-Pyrrolidine-2-carboxamide HCl;(2S)-pyrrolidine-2-carboxamide;hydrochloride;EINECS 255-818-2;H-Pro-NH2.HCl;H-Pro-NH HCl;L-Proline amide HCl;L-(-)-PROLINAMIDE HYDROCHLORIDE;prolinamide hydrochloride;L-Pro-NH2⋅HCl;proline amide hydrochloride;C5H10N2O.ClH;SCHEMBL241227;C5-H10-N2-O.Cl-H;DTXSID10195214;CSKSDAVTCKIENY-WCCKRBBISA-N;MFCD00058156;AKOS016843692;AM82206;CS-W018129;HY-W017413;AS-50380;PD196999;(S)-Pyrrolidine-2-carboxamidehydrochloride;EN300-315545;P10052;(s)-pyrrolidine-2-carboxamide hydrochloride salt;A825896;W-106273;56433-35-3

Chemical Property of (S)-Pyrrolidine-2-carboxamide monohydrochloride

Chemical Property:

• Vapor Pressure: 0.000923mmHg at 25°C
• Melting Point: 178-182 ºC
• Boiling Point: 303.6 ºC at 760 mmHg
• Flash Point: 137.4 ºC
• PSA: 55.12000
• LogP: 1.05480
• Storage Temp.: -15°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 150.0559907
• Heavy Atom Count: 9
• Complexity: 103

Purity/Quality:

99% ^*data from raw suppliers

L-Proline amide hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC(NC1)C(=O)N.Cl
• Isomeric SMILES: C1C[C@H](NC1)C(=O)N.Cl

Technology Process of (S)-Pyrrolidine-2-carboxamide monohydrochloride

There total 7 articles about (S)-Pyrrolidine-2-carboxamide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate (35150-07-3) → L-prolinamide hydrochloride (42429-27-6,50894-62-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1080/00397919408011723

Reference yield:

tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester (3392-10-7) → L-prolinamide hydrochloride (42429-27-6,50894-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 29 percent / NH₃(gas) / CHCl₃ / Ambient temperature

2: HCl / dioxane

With hydrogenchloride; ammonia; In 1,4-dioxane; chloroform;

DOI:10.1080/00397919408011723

Reference yield:

L-proline methyl ester monohydrochloride (2133-40-6) → L-prolinamide hydrochloride (42429-27-6,50894-62-7)

Guidance literature:

With ammonia; In methanol; for 72h; Ambient temperature;

DOI:10.1002/prac.19963380150

upstream raw materials:

Ac-Aib-L-Pro-NH₂

(S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate

L-proline methyl ester monohydrochloride

tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester

Downstream raw materials:

L-proline

[(R)-2-((S)-2-Carbamoyl-pyrrolidin-1-yl)-1-(4-methoxy-benzylsulfanylmethyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

[(S)-2-((S)-2-Carbamoyl-pyrrolidin-1-yl)-1-(4-hydroxy-2,6-dimethyl-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile

Refernces

• 1、 Kushwaha, Ram N.,Srivastava, Rohit,Mishra, Akansha,Rawat, Arun K.,Srivastava, Arvind K.,Haq, Wahajul,Katti, Seturam B.. "Design, synthesis, biological screening, and molecular docking studies of piperazine-derived constrained inhibitors of DPP-IV for the treatment of type 2 diabetes". . p. 439 - 446. Retrieved 2015/03/18.
• 2、 -. "Preparation of amino acid amides". Page/Page column 2. . Retrieved 2008/06/13.