Benzo[b]thiophene-3-acetic acid, a-amino-, (R)-

Base Information

• Chemical Name: Benzo[b]thiophene-3-acetic acid, a-amino-, (R)-
• CAS No.: 95909-98-1
• Molecular Formula: C10H9NO2S
• Molecular Weight: 207.24900
• Mol file: 95909-98-1.mol

Synonyms:(2R)-2-amino-2-(benzothiophen-3-yl)acetic acid;(R)-3-benzothienylglycine;(R)-Amino-benzo[b]thiophen-3-yl-acetic acid;

Chemical Property of Benzo[b]thiophene-3-acetic acid, a-amino-, (R)-

Chemical Property:

• PSA: 91.56000
• LogP: 2.68600

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzo[b]thiophene-3-acetic acid, a-amino-, (R)-

There total 4 articles about Benzo[b]thiophene-3-acetic acid, a-amino-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

<2-(hydroxyimino)-3-benzothienyl>acetic acid (95835-19-1) → (R)-3-benzothienylglycine (95909-98-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.35 g / H₂ / 5 percent Pd/C / methanol / 3 h / 24 °C / 3102.9 Torr

2: 92 percent / thionyl chloride / 2 h / Heating

4: 3.09 g / 2.22 N NaOH / 0.25 h / 25 °C

With sodium hydroxide; thionyl chloride; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00150a024

Reference yield:

methyl (R)-3-benzothienylglycinate (95909-97-0) → (R)-3-benzothienylglycine (95909-98-1)

Guidance literature:

With sodium hydroxide; at 25 ℃; for 0.25h;

DOI:10.1021/jm00150a024

Reference yield:

(RS)-3-benzothienylglycine (95834-55-2) → (R)-3-benzothienylglycine (95909-98-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / thionyl chloride / 2 h / Heating

3: 3.09 g / 2.22 N NaOH / 0.25 h / 25 °C

With sodium hydroxide; thionyl chloride;

DOI:10.1021/jm00150a024

upstream raw materials:

methyl (R)-3-benzothienylglycinate

<2-(hydroxyimino)-3-benzothienyl>acetic acid

(RS)-3-benzothienylglycine

methyl (RS)-3-benzothienylglycinate

Downstream raw materials:

(R)-7-(3-benzothienylglycylamido)-3-methyl-3-cephem-4-carboxylic acid

Refernces