gamma-carboline

Base Information

• Chemical Name: gamma-carboline
• CAS No.: 244-69-9
• Molecular Formula: C11H8 N2
• Molecular Weight: 168.198
• Hs Code.: 2933990090
• Mol file: 244-69-9.mol

Synonyms:3-Azacarbazole;3-Azarbazole; NSC 160470; g-Carboline

Chemical Property of gamma-carboline

Chemical Property:

• Vapor Pressure: 5.62E-06mmHg at 25°C
• Melting Point: 230-231℃ (methanol water )
• Refractive Index: 1.664 (589.3 nm 25℃)
• Boiling Point: 391.3°Cat760mmHg
• PKA: 15.08±0.30(Predicted)
• Flash Point: 182.1°C
• PSA: 28.68000
• Density: 1.301g/cm³
• LogP: 2.71610
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

5H-Pyrido[4,3-b]indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of gamma-carboline

There total 5 articles about gamma-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-azidophenyl)pyridine (856849-78-0) → γ-carboline (244-69-9) + α-carboline (244-76-8)

Guidance literature:

With decalin; at 180 ℃;

DOI:10.1021/ja01150a061

Reference yield:

3-(2-azidophenyl)pyridine (856849-78-0) + decalin (91-17-8) → γ-carboline (244-69-9) + α-carboline (244-76-8)

Guidance literature:

at 180 ℃;

DOI:10.1021/ja01150a061

Reference yield:

N-acetyl-3-bromo-4-piperidone hydrobromide + 4-bromophenylhydrazine hydrochloride (622-88-8,41931-18-4) → γ-carboline (244-69-9) + 8-bromo-5H-pyridine[4,3-b]indole (1015460-56-6)

Guidance literature:

With boron trifluoride diethyl etherate; at 230 ℃; for 0.0833333h; microwave irradiation;

DOI:10.1055/s-2007-992411

upstream raw materials:

3-(2-azidophenyl)pyridine

decalin

1-(3-nitro-4-pyridyl)-benzo-1,2,3-triazole

3-bromophenylhydrazine hydrochloride

Downstream raw materials:

5-(3-bromophenyl)-5H-pyrido[4,3-b]indole

2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

γ-carboline 2-oxide

5-methyl-5H-pyrido[4,3-b]indole

Refernces

• 1、 Chen, Jing,Chen, Weiliang,Hu, Yongzhou. "Microwave-enhanced Fischer reaction: An efficient one-pot synthesis of γ-carbolines". . p. 77 - 82. Retrieved 2008/09/21.