(E)-1-(4-Methoxy-3-nitrophenyl)-N-methylmethanimine

Base Information

• Chemical Name: (E)-1-(4-Methoxy-3-nitrophenyl)-N-methylmethanimine
• CAS No.: 96014-61-8
• Molecular Formula: C9H10N2O3
• Molecular Weight: 194.19
• DSSTox Substance ID: DTXSID30537819
• Mol file: 96014-61-8.mol

Synonyms:96014-61-8;(E)-1-(4-Methoxy-3-nitrophenyl)-N-methylmethanimine;DTXSID30537819

Chemical Property of (E)-1-(4-Methoxy-3-nitrophenyl)-N-methylmethanimine

Chemical Property:

• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 194.06914219
• Heavy Atom Count: 14
• Complexity: 225

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN=CC1=CC(=C(C=C1)OC)[N+](=O)[O-]

Technology Process of (E)-1-(4-Methoxy-3-nitrophenyl)-N-methylmethanimine

There total 2 articles about (E)-1-(4-Methoxy-3-nitrophenyl)-N-methylmethanimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-nitro-4-methoxybenzylidenemethylethylammonium fluoroborate + methylamine (74-89-5) → 3-nitro-4-methoxybenzylidenemethylamine (96014-61-8)

Guidance literature:

In ethanol; at 20 ℃; for 1h; Product distribution;

Reference yield: 80.0%

methylamine (74-89-5) + 4-methoxy-3-nitrobenzaldehyde (31680-08-7) → 3-nitro-4-methoxybenzylidenemethylamine (96014-61-8)

Guidance literature:

In ethanol; dichloromethane; for 1h;

Reference yield: 33.0%

3-nitro-4-methoxybenzylidenemethylamine (96014-61-8) + methylamine (74-89-5) → 4-(methylamino)-3-nitrobenzaldehyde (42564-41-0)

Guidance literature:

In ethanol; at 20 ℃; for 240h; Product distribution;

upstream raw materials:

methylamine

4-methoxy-3-nitrobenzaldehyde

Downstream raw materials:

4-dimethylamino-3-nitrobenzaldehyde

4-(methylamino)-3-nitrobenzaldehyde

1-methyl-4-(3,4,5-trimethoxyphenyl)-5-(3-nitro-4-methoxyphenyl)imidazole

2-methoxy-5-(1-methyl-4-(3,4,5-trimethoxyphenyl)-1 H-imidazol-5-yl)phenylamine

Refernces

• 1、 Wang, Le,Woods, Keith W.,Li, Qun,Barr, Kenneth J.,McCroskey, Richard W.,Hannick, Steven M.,Gherke, Laura,Credo, R. Bruce,Hui, Yu-Hua,Marsh, Kennan,Warner, Robert,Lee, Jang Y.,Zielinski-Mozng, Nicolette,Frost, David,Rosenberg, Saul H.,Sham, Hing L.. "Potent, orally active heterocycle-based combretastatin A-4 analogues: Synthesis, structure - Activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation". . p. 1697 - 1711. Retrieved 2007/10/03.