Niaprazine

Base Information

• Chemical Name: Niaprazine
• CAS No.: 27367-90-4
• Molecular Formula: C₂₀H₂₅FN₄O
• Molecular Weight: 356.443
• Hs Code.: 2933599090
• European Community (EC) Number: 248-431-5,620-536-4
• UNII: 5QKW305N9F,1346Q758L9,R2H3YN6E3L
• DSSTox Substance ID: DTXSID10865369
• Nikkaji Number: J10.716F
• Wikipedia: Niaprazine
• Wikidata: Q631457
• NCI Thesaurus Code: C76943
• Metabolomics Workbench ID: 154475
• ChEMBL ID: CHEMBL2105141
• Mol file: 27367-90-4.mol

Synonyms:niaprazine;niaprazine trihydrochloride;Nopron

Chemical Property of Niaprazine

Chemical Property:

• Vapor Pressure: 2.36E-13mmHg at 25°C
• Melting Point: 131 °C
• Refractive Index: 1.566
• Boiling Point: 577.9 °C at 760 mmHg
• Flash Point: 303.3 °C
• PSA: 51.96000
• Density: 1.165 g/cm³
• LogP: 3.12900
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 356.20123960
• Heavy Atom Count: 26
• Complexity: 434

Purity/Quality:

98%Min ^*data from raw suppliers

Niaprazine 98.86% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CCN1CCN(CC1)C2=CC=C(C=C2)F)NC(=O)C3=CN=CC=C3
• Uses: Niaprazine comprises norepinephrine reuptake inhibitors (NRIs), non-myorelaxing hypnotic agents and 5-HT2A inverse agonists or antagonists for treating sleep apnea.
• Therapeutic Function: Antihistaminic

Technology Process of Niaprazine

There total 1 articles about Niaprazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (+)-Niaprazine (27367-90-4,119306-37-5,119328-74-4)

Guidance literature:

aus 1-(p-Fluorphenyl)-4-(3-amino-butyl)-piperazin und Nicotinsaeurechlorid;

Refernces