Carmofur

Base Information Edit

Chemical Name:Carmofur
CAS No.:61422-45-5
Molecular Formula:C11H16FN3O3
Molecular Weight:257.265
Hs Code.:29335990
European Community (EC) Number:689-431-9
NSC Number:758963
UNII:HA82M3RAB2
DSSTox Substance ID:DTXSID2045941
Nikkaji Number:J1.101K
Wikipedia:Carmofur
Wikidata:Q5043732
NCI Thesaurus Code:C955
Pharos Ligand ID:WN3HDW538SSQ
Metabolomics Workbench ID:152083
ChEMBL ID:CHEMBL460499
Mol file:61422-45-5.mol

Synonyms:1(2H)-pyrimidinecarboxamide, 5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-;1-hexylcarbamoyl-5-fluorouracil;carmofur;HCFU;Mifurol;N-hexylcarbamoyl-5-fluorouracil

Suppliers and Price of Carmofur

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Carmofur
500mg
$ 110.00

TCI Chemical
Carmofur >98.0%(HPLC)(T)
5g
$ 233.00

SynQuest Laboratories
1-(n-Hexylcarbamoyl)-5-fluorouracil 98%
5 g
$ 95.00

SynQuest Laboratories
1-(n-Hexylcarbamoyl)-5-fluorouracil 98%
1 g
$ 45.00

Sigma-Aldrich
Carmofur ≥98% (HPLC), powder
50mg
$ 324.00

Sigma-Aldrich
Carmofur ≥98% (HPLC), powder
10mg
$ 79.80

Crysdot
Carmofur 98+%
100mg
$ 92.00

ChemScene
Carmofur 99.95%
500mg
$ 84.00

ChemScene
Carmofur 99.95%
100mg
$ 60.00

Chem-Impex
Carmofur,98%(Assaybytitration,HPLC) 98%(Assaybytitration,HPLC)
5G
$ 189.28

Total 70 raw suppliers

Chemical Property of Carmofur Edit

Chemical Property:

Melting Point:110-111 °C
Refractive Index:1.525
PKA:6.94±0.10(Predicted)
PSA：83.96000
Density:1.26 g/cm³
LogP:1.20460
Storage Temp.:2-8°C
Solubility.:DMSO: >15mg/mL
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:257.11756954
Heavy Atom Count:18
Complexity:382

Purity/Quality:

99% ^*data from raw suppliers

Carmofur ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,T
Statements: 60-61-25
Safety Statements: 45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCCCCNC(=O)N1C=C(C(=O)NC1=O)F
Description Carmofur is an inhibitor of acid ceramidase (IC50 = 79 nM for the rat enzyme) and a derivative of 5-flurouracil . It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of various ceramide species, including C18 ceramide , C16 ceramide , and C14 ceramide in SW403 colon and LNCaP prostate cancer cells. Carmofur induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC50 = 1,212 mM for human thymidylate synthetase). It also reduces acid ceramidase activity and increases ceramide accumulation in mouse lung and brain when administered at doses of 10 and 30 mg/kg.
Uses antineoplastic Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .
Therapeutic Function Antineoplastic

Technology Process of Carmofur

There total 2 articles about Carmofur which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: