2-ETHYLPYRROLE

Base Information

• Chemical Name: 2-ETHYLPYRROLE
• CAS No.: 1551-06-0
• Molecular Formula: C6H9N
• Molecular Weight: 95.1442
• Hs Code.: 29339980
• Mol file: 1551-06-0.mol

Synonyms:2-Ethylpyrrole;2-Ethyl-1H-pyrrole;alpha-Ethyl pyrrole;Pyrrole,2-ethyl- (6CI,7CI,8CI);

Chemical Property of 2-ETHYLPYRROLE

Chemical Property:

• Appearance/Colour: clear yellow liquid
• Vapor Pressure: 2.63mmHg at 25°C
• Melting Point: 6.5°C (estimate)
• Refractive Index: n20/D 1.497(lit.)
• Boiling Point: 164 °C at 760 mmHg
• PKA: 17?+-.0.50(Predicted)
• Flash Point: 62.2 °C
• PSA: 15.79000
• Density: 0.945 g/cm³
• LogP: 1.57710
• Storage Temp.: Refrigerator

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Ethylpyrrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Ethylpyrrole may be used in the preparation of 1-(3-methoxyphenyl)-2-ethylpyrrole.

Technology Process of 2-ETHYLPYRROLE

There total 27 articles about 2-ETHYLPYRROLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Acetylpyrrole (1072-83-9) → 2-ethyl-1H-pyrrole (1551-06-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

DOI:10.1002/anie.202104794

Reference yield: 81.0%

2-acetyl-1-(4-toluenesulfonyl)pyrrole (129666-99-5) → 2-ethyl-1H-pyrrole (1551-06-0)

Guidance literature:

With sodium tetrahydroborate; In isopropyl alcohol; at 0 - 85 ℃; for 26h; Inert atmosphere;

DOI:10.1021/ja400473v

Reference yield: 64.0%

1-Benzenesulfonyl-2-ethyl-1H-pyrrole (97188-25-5) → 2-ethyl-1H-pyrrole (1551-06-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 24h; Heating;

DOI:10.1016/S0040-4039(97)10653-0

upstream raw materials:

1-ethylpyrrolidine

2-ethenyl-1H-pyrrole

1-ethyl-1H-pyrrole

pyrrole

Downstream raw materials:

5-ethylpyrrole-2,4-dicarboxaldehyde

2-ethyl-1-(2-methyl-2-propenyl)pyrrole

1-(3-methoxyphenyl)-2-ethylpyrrole

3-[(5-ethyl-1H-pyrrol-2-yl)-carbonyl]-benzonitrile

Refernces

• 1、 Akhmanova, Anna,Heise, Constanze,Meiring, Joyce C. M.,Pettersson, Linda N.,Sailer, Alexander,Thorn-Seshold, Julia,Thorn-Seshold, Oliver. "Pyrrole Hemithioindigo Antimitotics with Near-Quantitative Bidirectional Photoswitching that Photocontrol Cellular Microtubule Dynamics with Single-Cell Precision**". supporting information. p. 23695 - 23704. Retrieved 2021/10/05.
• 2、 Sch?fer, Clara,Mony, Jürgen,Olsson, Thomas,B?rjesson, Karl. "Entropic Mixing Allows Monomeric-Like Absorption in Neat BODIPY Films". supporting information. p. 14295 - 14299. Retrieved 2020/10/06.