3-(Methoxymethoxy)aniline

Base Information

• Chemical Name: 3-(Methoxymethoxy)aniline
• CAS No.: 96649-05-7
• Molecular Formula: C8H11NO2
• Molecular Weight: 153.181
• Hs Code.: 2922190090
• European Community (EC) Number: 894-860-1
• Mol file: 96649-05-7.mol

Synonyms:3-(methoxymethoxy)aniline;96649-05-7;3-Methoxymethoxy-phenylamine;3-Methoxymethoxyphenylamine;SCHEMBL4701907;3-Aminophenyl Methoxymethyl Ether;LYUGTXVKEWULGQ-UHFFFAOYSA-N;MFCD21195211;AKOS014701600;GS-5516;SB76344;CS-0210409;H10442;EN300-1249333

Chemical Property of 3-(Methoxymethoxy)aniline

Chemical Property:

• Boiling Point: 89-91 °C (0.3 mmHg)
• PSA: 44.48000
• Density: 1.105±0.06 g/cm3(20 °C , 760mmHg)
• LogP: 1.83270
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 153.078978594
• Heavy Atom Count: 11
• Complexity: 108

Purity/Quality:

0% ^*data from raw suppliers

3-(Methoxymethoxy)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCOC1=CC=CC(=C1)N

Technology Process of 3-(Methoxymethoxy)aniline

There total 5 articles about 3-(Methoxymethoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(methoxymethoxy)-3-nitrobenzene (25458-48-4) → 3-(methoxymethoxy)aniline (96649-05-7)

Guidance literature:

With aluminium amalgam; In diethyl ether; water;

DOI:10.1021/jo971686p

Reference yield: 89.0%

Al-Hg + 1-(methoxymethoxy)-3-nitrobenzene (25458-48-4) → 3-(methoxymethoxy)aniline (96649-05-7)

Guidance literature:

Reference yield:

meta-nitrophenol (554-84-7) → 3-(methoxymethoxy)aniline (96649-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / NaH, Bu₄NI

2: 89 percent / Al-Hg / diethyl ether; H₂O

With aluminium amalgam; tetra-(n-butyl)ammonium iodide; sodium hydride; In diethyl ether; water;

DOI:10.1021/jo971686p

upstream raw materials:

chloromethyl methyl ether

m-Hydroxyaniline

1-(methoxymethoxy)-3-nitrobenzene

meta-nitrophenol

Refernces

• 1、 Yang, Zhuang,Wang, Taijin,Wang, Fang,Niu, Ting,Liu, Zhuowei,Chen, Xiaoxin,Long, Chaofeng,Tang, Minghai,Cao, Dong,Wang, Xiaoyan,Xiang, Wei,Yi, Yuyao,Ma, Liang,You, Jingsong,Chen, Lijuan. "Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer". . p. 1455 - 1470. Retrieved 2016/03/08.
• 2、 -. "4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives". Page/Page column 60. . Retrieved 2010/11/26.