Ohmefentanyl

Base Information

• Chemical Name: Ohmefentanyl
• CAS No.: 78995-14-9
• Molecular Formula: C₂₃H₃₀N₂O₂
• Molecular Weight: 366.503
• UNII: Y8263089ZX
• DSSTox Substance ID: DTXSID50868495
• Nikkaji Number: J33.890G
• Wikipedia: Ohmefentanyl
• Wikidata: Q107125128
• Metabolomics Workbench ID: 146218
• ChEMBL ID: CHEMBL333410
• Mol file: 78995-14-9.mol

Synonyms:7302;F 7302;F-7302;N-(1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl)-N-phenylpropanamide;N-(1-(beta-hydroxy beta-phenethyl)-3-methyl-4-piperidyl)-N-phenylpropionamide;ohmefentanyl;RTI 46144;RTI 6414-4;RTI-4614-4;RTI-46144;RTI-6414-4

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Ohmefentanyl

Chemical Property:

• Vapor Pressure: 1.69E-11mmHg at 25°C
• Boiling Point: 516.6°Cat760mmHg
• Flash Point: 266.2°C
• PSA: 43.78000
• Density: 1.118g/cm³
• LogP: 3.81150
• Storage Temp.: -20°C Freezer
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 366.230728204
• Heavy Atom Count: 27
• Complexity: 457

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)N(C1CCN(CC1C)CC(C2=CC=CC=C2)O)C3=CC=CC=C3
• Uses: A prodrug opioid. A Fentanyl analog. Controlled Substance

Technology Process of Ohmefentanyl

There total 56 articles about Ohmefentanyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(+/-)-cis-N-<1-(2-oxo-2-phenylethyl)-3-methyl-4-piperidyl>-N-phenylpropanamide → (+/-)-cis-N-<1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl>-N-phenylpropanamide (78995-14-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 4h; Heating;

DOI:10.1002/jhet.5570290717

Reference yield:

1-benzyl-3-methyl-N-phenyl-4-piperidinamine (58329-00-3) → F 9205 (78995-14-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 8.9 g / H₂ / 10percent Pd/C / ethanol / 6 h / 60 °C / 775.7 Torr

3: 0.6 g / ethanol / 5 h / 50 °C

4: toluene / 5 h / Heating

5: K₂CO₃ / methanol; H₂O / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; ethanol; water; toluene;

DOI:10.1021/jm00018a026

Reference yield:

1-benzyl-3-methyl-N-phenyl-4-piperidinamine (58329-00-3) → F 9207 (78995-14-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 8.9 g / H₂ / 10percent Pd/C / ethanol / 6 h / 60 °C / 775.7 Torr

3: 81 percent / 1 h / 100 °C

4: toluene / 5 h / Heating

5: K₂CO₃ / methanol; H₂O / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; ethanol; water; toluene;

DOI:10.1021/jm00018a026

upstream raw materials:

styrene oxide

cis-N-<3-methyl-4-piperidinyl>-N-phenylpropanamide

α-bromoacetophenone

(3S,4R,2'R)-cis-N-<1-<2-(propionyloxy)-2-phenylethyl>-3-methyl-4-piperidyl>-N-phenylpropanamide

Refernces

• 1、 Wang,Zhu,Jin,Chen,Chen,Ji,Chi. "Stereoisomers of N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N- phenylpropanamide: Synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics". . p. 3652 - 3659. Retrieved 2007/10/03.