5-(4-Methoxyphenyl)-2-(pyridin-4-yl)oxazole

Base Information

• Chemical Name: 5-(4-Methoxyphenyl)-2-(pyridin-4-yl)oxazole
• CAS No.: 96753-33-2
• Molecular Formula: C15H12N2O2
• Molecular Weight: 252.26800
• Mol file: 96753-33-2.mol

Synonyms:2-(4-pyridyl)-5-(4-methoxyphenyl)-oxazole;Pyridine,4-[5-(4-methoxyphenyl)-2-oxazolyl];4-[5-(4-Methoxyphenyl)-2-oxazolyl]pyridine;5-(4-methoxyphenyl)-2-(4-pyridyl)oxazole;

Chemical Property of 5-(4-Methoxyphenyl)-2-(pyridin-4-yl)oxazole

Chemical Property:

• PSA: 48.15000
• LogP: 3.41220

Purity/Quality:

97% ^*data from raw suppliers

5-(4-Methoxyphenyl)-2-(pyridin-4-yl)oxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-Methoxyphenyl)-2-(pyridin-4-yl)oxazole

There total 12 articles about 5-(4-Methoxyphenyl)-2-(pyridin-4-yl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

pyridine-4-carboxylic acid (55-22-1) + 2-amino-4'-methoxyacetophenone hydrochloride (3883-94-1) → 2-(4-pyridyl)-5-(4-methoxyphenyl)-oxazole (96753-33-2)

Guidance literature:

With trichlorophosphate; for 6h; Heating;

DOI:10.1002/chem.200500619

Reference yield: 77.0%

N-(2-(4-methoxyphenyl)-2-oxoethyl)isonicotinamide (932389-85-0) → 2-(4-pyridyl)-5-(4-methoxyphenyl)-oxazole (96753-33-2)

Guidance literature:

With sulfuric acid; for 0.75h; 1.) reflux, 1 h, 2.) 22 deg C, overnight;

Reference yield:

2-(p-methoxyphenyl)ethan-1,2-dion-1-oxime sodium salt (151427-04-2) → 2-(4-pyridyl)-5-(4-methoxyphenyl)-oxazole (96753-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / H₂ / 10percent Pd/C / methanol / 2 h

2: 72 percent / POCl₃ / 6 h / Heating

With hydrogen; trichlorophosphate; palladium on activated charcoal; In methanol;

upstream raw materials:

pyridine-4-carboxylic acid

2-amino-1-(4-methoxy-phenyl)-ethanone

2-amino-4'-methoxyacetophenone hydrochloride

N-(2-(4-methoxyphenyl)-2-oxoethyl)isonicotinamide

Downstream raw materials:

Toluene-4-sulfonate1-ethyl-4-[5-(4-methoxy-phenyl)-oxazol-2-yl]-pyridinium;

1-methyl-4-[5-(4'-methoxyphenyl)-2-oxazolyl]pyridinium p-toluenesulfonate

1-Benzyl-4-[5-(4-methoxy-phenyl)-oxazol-2-yl]-pyridinium; chloride

4-(5-Phenyl-oxazol-2-yl)-benzenesulfonate4-[5-(4-methoxy-phenyl)-oxazol-2-yl]-1-methyl-pyridinium;

Refernces

• 1、 Zhu, Qing,Yoon, Hai-Shin,Parikh, Puja B.,Chang, Young-Tae,Yao, Shao Q.. "Combinatorial discovery of novel fluorescent dyes based on Dapoxyl". . p. 5083 - 5086. Retrieved 2007/10/03.
• 2、 Alekseeva, V. I.,Afanasiadi, L. Sh.,Volkov, V. M.,Krasovitskii, B. M.,Vernigor, E. M.,et al.. "SPECTRAL-LUMINESCENT AND LASING PROPERTIES OF PYRIDYLARYLOXAZOLES". . p. 244 - 247. Retrieved 2007/10/02.