Butanal, 3-methyl-2-(phenylmethoxy)-

Base Information

• Chemical Name: Butanal, 3-methyl-2-(phenylmethoxy)-
• CAS No.: 96925-01-8
• Molecular Formula: C12H16O2
• Molecular Weight: 192.258
• Mol file: 96925-01-8.mol

Synonyms:

Chemical Property of Butanal, 3-methyl-2-(phenylmethoxy)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Butanal, 3-methyl-2-(phenylmethoxy)-

There total 17 articles about Butanal, 3-methyl-2-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

3-(benzyloxy)-4-methylpent-1-ene (128950-60-7) → 2-(Benzyloxy)-3-methylbutanal (96925-01-8)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; In water; isopropyl alcohol; for 60h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b01161

Reference yield:

(E,R)-[(2-methyldec-4-en-3-yloxy)methyl]benzene (1263469-84-6) → (R)-2-(benzyloxy)-3-methylbutanal (96925-01-8,110840-39-6,149342-56-3,84994-60-5)

Guidance literature:

(E,R)-[(2-methyldec-4-en-3-yloxy)methyl]benzene; With ozone; In methanol; dichloromethane; at -78 ℃; for 0.0833333h;

With dimethylsulfide; In dichloromethane; at -78 - 20 ℃; for 12h;

DOI:10.1021/ol102936z

Reference yield:

4-methyl-pent-1-en-3-ol (4798-45-2,73262-52-9,132486-36-3,132486-37-4) → 2-(Benzyloxy)-3-methylbutanal (96925-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) reflux, 12-20 h

2: 1.) ozone, 2.) dimethyl sulfide / 1.) dichloromethane, -78 deg C, 2.) -78 deg C to room temperature, 2-3 h, then room temperature, 12 h

With dimethylsulfide; sodium hydride; ozone;

DOI:10.1021/jo00304a018

upstream raw materials:

benzyl bromide

(R)-2-Methyl-1-((S)-2-phenyl-hexahydro-pyrrolo[1,2-c]imidazol-3-yl)-propan-1-ol

3-(benzyloxy)-4-methylpent-1-ene

2-Benzyloxy-3-methyl-butan-1-ol

Downstream raw materials:

(S)-2-(benzyloxy)-3-methylbutane-1-ol

(R)-2-benzyloxy-3-methyl-1-butanol

benzyl 2-methylpropanoate

N-(4-methylphenyl)formamide

Refernces

• 1、 Hu, Bin,Li, Yunfeng,Li, Zhongjun,Meng, Xiangbao. "Aniline mediated oxidative C-C bond cleavage of α-alkoxy aldehydes in air and a model reaction for the synthesis of α-(d)-amino acid derivatives". . p. 4138 - 4141. Retrieved 2013/07/05.
• 2、 Gung, Benjamin W.,Melnick, Jason P.,Wolf, Mark A.,King, Amanda. "Steric and Electronic Effects in Conformational Preferences of C1-Oxygenated Chiral Alkenes". . p. 1947 - 1951. Retrieved 2007/10/02.