N,N-DIPHENYL-METHANESULFONAMIDE

Base Information

• Chemical Name: N,N-DIPHENYL-METHANESULFONAMIDE
• CAS No.: 3989-43-3
• Molecular Formula: C13H13NO2S
• Molecular Weight: 247.318
• Hs Code.: 2935009090
• Mol file: 3989-43-3.mol

Synonyms:4-(Methylsulfonyl)diphenylamine;N,N-Diphenylmethanesulfonamide;NSC 116559;

Chemical Property of N,N-DIPHENYL-METHANESULFONAMIDE

Chemical Property:

• Vapor Pressure: 5.47E-06mmHg at 25°C
• Melting Point: 116.5-117.0 °C(Solv: methanol (67-56-1))
• Refractive Index: 1.623
• Boiling Point: 380.4 °C at 760 mmHg
• PKA: -6.41±0.50(Predicted)
• Flash Point: 183.8 °C
• PSA: 45.76000
• Density: 1.267 g/cm³
• LogP: 3.86510

Purity/Quality:

99% ^*data from raw suppliers

N,N-DIPHENYL-METHANESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-DIPHENYL-METHANESULFONAMIDE

There total 4 articles about N,N-DIPHENYL-METHANESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-phenylmethanesulfonamide (1197-22-4) + phenylboronic acid (98-80-6) → N,N-diphenylmethanesulfonamide (3989-43-3)

Guidance literature:

With N-methylcyclohexylamine; tetrakis(actonitrile)copper(I) hexafluorophosphate; In acetonitrile; at 20 ℃; Reagent/catalyst;

DOI:10.1021/acscatal.8b03238

Reference yield: 80.0%

methanesulfonamide (3144-09-0) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → N,N-diphenylmethanesulfonamide (3989-43-3)

Guidance literature:

With cesium fluoride; In acetonitrile; at 25 ℃; for 24h;

DOI:10.1021/ol0358612

Reference yield: 79.0%

N-phenylmethanesulfonamide (1197-22-4) + 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole (24388-23-6) → N,N-diphenylmethanesulfonamide (3989-43-3)

Guidance literature:

With potassium phosphate; tetrakis(actonitrile)copper(I) hexafluorophosphate; In acetonitrile; at 20 ℃; Reagent/catalyst;

DOI:10.1021/acscatal.8b03238

upstream raw materials:

methanesulfonyl chloride

diphenylamine

methanesulfonamide

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

Downstream raw materials:

diphenylamine

Refernces

• 1、 Liu, Zhijian,Larock, Richard C.. "Facile N-arylation of amines and sulfonamides and O-arylation of phenols and arenecarboxylic acids". . p. 3198 - 3209. Retrieved 2007/10/03.
• 2、 Ruosteuso, P.,Haekkinen, A.-M.,Mattila, T.. "Multinuclear NMR Study of Variously Substituted Sulphonamides and Sulphinamides". . p. 189 - 193. Retrieved 2007/10/02.