N-benzyl-2,4-dinitroaniline

Base Information

• Chemical Name: N-benzyl-2,4-dinitroaniline
• CAS No.: 7403-38-5
• Molecular Formula: C13H11 N3 O4
• Molecular Weight: 273.248
• Hs Code.: 2921499090
• Mol file: 7403-38-5.mol

Synonyms:Benzylamine,N-(2,4-dinitrophenyl)- (6CI,7CI,8CI); N-Benzyl-2,4-dinitroaniline; NSC 404032

Chemical Property of N-benzyl-2,4-dinitroaniline

Chemical Property:

• Vapor Pressure: 4.26E-08mmHg at 25°C
• Boiling Point: 444.5°Cat760mmHg
• Flash Point: 222.6°C
• PSA: 103.67000
• Density: 1.413g/cm³
• LogP: 4.23450

Purity/Quality:

99% ^*data from raw suppliers

N-Benzyl-N-(2,4-dinitrophenyl)amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-2,4-dinitroaniline

There total 19 articles about N-benzyl-2,4-dinitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-amino-1-(2,4-dinitrophenyl)-1H-pyrazole-4-carbonitrile (75008-95-6) + benzylamine (100-46-9) → N-benzyl-2,4-dinitroaniline (7403-38-5)

Guidance literature:

In ethanol; for 2h; Reflux;

DOI:10.3184/030823408X338693

Reference yield: 88.0%

2,4-Dinitrofluorobenzene (70-34-8,65727-75-5) + benzylamine (100-46-9) → N-benzyl-2,4-dinitroaniline (7403-38-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm201023g

Reference yield: 84.0%

N-Benzylaniline (758640-21-0,103-32-2) → N-benzyl-2,4-dinitroaniline (7403-38-5)

Guidance literature:

With bismuth (III) nitrate pentahydrate; palladium diacetate; In 2,2,2-trifluoroethanol; trifluoroacetic acid; at 20 - 90 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tet.2015.04.013

upstream raw materials:

2,4-Dinitrofluorobenzene

benzylamine

1-chloro-2,4-dinitro-benzene

2,4-dinitrobromobenzene

Downstream raw materials:

2-[(6-nitro-2-phenyl-1H-1,3-benzimidazol-1-yl)oxy]acetic acid

Refernces

• 1、 Wilhelmsen, Christopher A.,Dixon, Alexandre D.C.,Chisholm, John D.,Clark, Daniel A.. "Synthesis of N-Substituted 3-Amino-4-halopyridines: A Sequential Boc-Removal/Reductive Amination Mediated by Br?nsted and Lewis Acids". . p. 1634 - 1642. Retrieved 2018/02/09.
• 2、 Ormazábal-Toledo, Rodrigo,Contreras, Renato,Tapia, Ricardo A.,Campodónico, Paola R.. "Specific nucleophile-electrophile interactions in nucleophilic aromatic substitutions". supporting information. p. 2302 - 2309. Retrieved 2013/04/10.