Succinylcholine

Base Information

• Chemical Name: Succinylcholine
• CAS No.: 306-40-1
• Molecular Formula: C₁₄H₃₀N₂O₄
• Molecular Weight: 290.403
• Hs Code.: 2923900090
• European Community (EC) Number: 200-747-4
• UNII: J2R869A8YF
• DSSTox Substance ID: DTXSID7048455
• Nikkaji Number: J11.690D
• Wikipedia: Suxamethonium_chloride
• Wikidata: Q424378
• NCI Thesaurus Code: C61955
• RXCUI: 10154
• Pharos Ligand ID: S3V4TVFMHM5J
• Metabolomics Workbench ID: 42607
• ChEMBL ID: CHEMBL703
• Mol file: 306-40-1.mol

Synonyms:Anectine;Bromide, Suxamethonium;Celocurine;Dibromide, Succinylcholine;Dichloride, Succinylcholine;dicholine succinate;Diiodide, Succinylcholine;Diperchlorate, Succinylcholine;Ditilin;Listenon;Lysthenon;Myorelaxin;Quelicin;Succicuran;Succinate, Dicholine;Succinylcholine;Succinylcholine Chloride;Succinylcholine Dibromide;Succinylcholine Dichloride;Succinylcholine Dichloride, Di H2O;Succinylcholine Dichloride, Di-H2O;Succinylcholine Diiodide;Succinylcholine Diperchlorate;Succinylcholine Iodide;Succinyldicholine;Suxamethonium;Suxamethonium Bromide;Suxamethonium Chloride

Chemical Property of Succinylcholine

Chemical Property:

• Refractive Index: 1.5060 (estimate)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 52.60000
• Density: g/cm³
• LogP: 0.26540
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 11
• Exact Mass: 290.22055744
• Heavy Atom Count: 20
• Complexity: 284

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Safety Statements: Poison by ingestion, intraperitoneal, intravenous,and subcutaneous routes. Human systemic effects by intravenous route: changes

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C
• Recent ClinicalTrials: Intubating Conditions During Rapid Sequence Induction in Elderly With Either Suxamethonium 1.0 mg/kg or Rocuronium 1.0 mg/kg
• Recent EU Clinical Trials: A single blinded multicenter randomized study comparing intubating conditions during rapid sequence induction with either suxamethonium 1.0 mg/kg or rocuronium 1.0 mg/kg in elderly patients (≥ 80 years old)
• Recent NIPH Clinical Trials: Open lavel single center crossover study concerning the change of PVI(Pleth Variability Index) and SVV(Stroke Volume Valiance) durung mECT(modified Electro Convulsive Therapy).
• Description: Succinylcholine is the only therapeutically used depolarizing neuromuscular blocker. Unlike nondepolarizing substances, succinylchloride is not a competitive antagonist; conversely, it is a more stable agonist than acetylcholine. In this manner, succinylcholine differs from acetylcholine only in duration—it lasts longer, causing a more stable depolarization. Thus the process of repolarization is blocked and the muscles relax. During this period, muscles that cause fine movement (ocular, facial, neck) are the most sensitive and are blocked first, after which muscles of the extremities are blocked, and finally the most stable respiratory muscles. Restoration occurs upon completion of drug action.
• Uses: Therapeutic use of succinylcholine consists of preventing involuntary patient movement. It is used for brief operations, intubation of the trachea, and other endoscopic procedures. Synonyms of this drug are listenon, midarine, sucostrin, ditilin, and others.
• Therapeutic Function: Muscle relaxant

Technology Process of Succinylcholine

There total 1 articles about Succinylcholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ succinylcholine (306-40-1)

Guidance literature:

Bernsteinsaeureanhydrid, Cholinchlorid (verb. Methode);