5-Pyrimidinecarboxylic acid, 1,4,5,6-tetrahydro-4-oxo-2,6-diphenyl-, 1-methylethyl ester

Base Information

• Chemical Name: 5-Pyrimidinecarboxylic acid, 1,4,5,6-tetrahydro-4-oxo-2,6-diphenyl-, 1-methylethyl ester
• CAS No.: 98010-97-0
• Molecular Formula: C₂₀H₂₀N₂O₃
• Molecular Weight: 336.39
• Mol file: 98010-97-0.mol

Synonyms:

Chemical Property of 5-Pyrimidinecarboxylic acid, 1,4,5,6-tetrahydro-4-oxo-2,6-diphenyl-, 1-methylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Pyrimidinecarboxylic acid, 1,4,5,6-tetrahydro-4-oxo-2,6-diphenyl-, 1-methylethyl ester

There total 1 articles about 5-Pyrimidinecarboxylic acid, 1,4,5,6-tetrahydro-4-oxo-2,6-diphenyl-, 1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

benzamidine monohydrochloride (1670-14-0) + diethyl benzalmalonate (5292-53-5) → 6-Oxo-2,4-diphenyl-1,4,5,6-tetrahydro-pyrimidine-5-carboxylic acid isopropyl ester (98010-97-0)

Guidance literature:

With sodium isopropylate; In isopropyl alcohol; for 5h; Ambient temperature;

DOI:10.1055/s-1985-31120

Reference yield: 20.0%

6-Oxo-2,4-diphenyl-1,4,5,6-tetrahydro-pyrimidine-5-carboxylic acid isopropyl ester (98010-97-0) → 5-Isopropoxycarbonyl-4-oxo-2,6-diphenyl-3,4-dihydropyrimidine (98011-59-7)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In isopropyl alcohol; for 1h; Ambient temperature;

DOI:10.1055/s-1985-31120

upstream raw materials:

benzamidine monohydrochloride

diethyl benzalmalonate

Downstream raw materials:

5-Isopropoxycarbonyl-4-oxo-2,6-diphenyl-3,4-dihydropyrimidine

Refernces