Pyrimido[5,4-d]pyrimidine (7CI,8CI,9CI)

Base Information

• Chemical Name: Pyrimido[5,4-d]pyrimidine (7CI,8CI,9CI)
• CAS No.: 254-82-0
• Molecular Formula: C₆H₄N₄
• Molecular Weight: 132.125
• Hs Code.: 2933990090
• Mol file: 254-82-0.mol

Synonyms:1,3,5,7-Tetraazanaphthalene;Homopurine

Chemical Property of Pyrimido[5,4-d]pyrimidine (7CI,8CI,9CI)

Chemical Property:

• PSA: 51.56000
• LogP: 0.41980

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimido[5,4-d]pyrimidine (7CI,8CI,9CI)

There total 1 articles about Pyrimido[5,4-d]pyrimidine (7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

pyrimidin-5-amine (591-55-9) + formamide (77287-34-4,77287-35-5,60100-09-6) → pyrimido[5,4-d]pyrimidine (254-82-0)

Guidance literature:

With phosphorus tribromide; at 50 - 60 ℃; Inert atmosphere;

DOI:10.1021/jo301463m

upstream raw materials:

pyrimidin-5-amine

formamide

Refernces

• 1、 Wong, Fung Fuh,Huang, Yu-Ying,Chang, Chun-Hsi. "Evaluation of electrophilic heteroaromatic substitution: Synthesis of heteroaromatic-fused pyrimidine derivatives via sequential three-component heterocyclization". . p. 8492 - 8500. Retrieved 2012/11/07.