9H-Carbazol-3-amine

Base Information

• Chemical Name: 9H-Carbazol-3-amine
• CAS No.: 6377-12-4
• Molecular Formula: C12H10 N2
• Molecular Weight: 182.225
• Hs Code.: 2933990090
• European Community (EC) Number: 228-946-1
• NSC Number: 49769
• UNII: QQJ9EB2BT3
• DSSTox Substance ID: DTXSID60213215
• Nikkaji Number: J206.981D
• Wikidata: Q72515190
• Mol file: 6377-12-4.mol

Synonyms:9H-Carbazol-3-amine;6377-12-4;9H-Carbazol-3-ylamine;3-Aminocarbazole;Carbazol-3-ylamine;Carbazole, 3-amino-;QQJ9EB2BT3;CCRIS 6504;EINECS 228-946-1;NSC 49769;NSC-49769;BRN 0142222;AI3-50579;NSC49769;UNII-QQJ9EB2BT3;Cambridge id 5172420;Oprea1_743249;SCHEMBL274921;9H-Carbazol-3-amine (9CI);DTXSID60213215;HMS1697K18;MFCD00022213;AKOS000152602;RS-0067;LS-51678;CS-0071522;FT-0677659;EN300-94650;Y11368;A915098;F1918-0083

Chemical Property of 9H-Carbazol-3-amine

Chemical Property:

• Vapor Pressure: 5.75E-08mmHg at 25°C
• Melting Point: 254 °C
• Boiling Point: 440.8°C at 760 mmHg
• PKA: 18.44±0.30(Predicted)
• Flash Point: 250.6°C
• PSA: 41.81000
• Density: 1.317g/cm³
• LogP: 3.48450
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 182.084398327
• Heavy Atom Count: 14
• Complexity: 216

Purity/Quality:

98.5% ^*data from raw suppliers

9H-Carbazol-3-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C(N2)C=CC(=C3)N

Technology Process of 9H-Carbazol-3-amine

There total 34 articles about 9H-Carbazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-Nitro-carbazol (3077-85-8) → 3-amino-9H-carbazole (6377-12-4)

Guidance literature:

With palladium 10% on activated carbon; hydrazine hydrate; In ethanol; at 80 ℃; for 24h; Inert atmosphere;

Reference yield: 90.0%

3-nitro-6-methoxy-9H-carbazole (155136-79-1) → 3-amino-9H-carbazole (6377-12-4)

Guidance literature:

With hydrazine hydrate; nickel; In ethanol; for 1h; Heating;

Reference yield: 89.0%

3-azidocarbazole (6310-80-1) → 3-amino-9H-carbazole (6377-12-4)

Guidance literature:

With iron(III)-acetylacetonate; hydrazine; In butan-1-ol; for 3h; Reflux;

upstream raw materials:

3-nitrosocarbazole

1-phenyl-1H-benzo[1,2,3]triazol-5-ylamine

3-Nitro-carbazol

3-nitro-9-nitroso-carbazole

Refernces

• 1、 Bergman, Jan,Janosik, Tomasz,Yudina, Larisa,Desarbre, Eric,Lidgren, G.?ran,Venemalm, Lennart. "Reactions of 1,2-bis(1H-indol-2-yl)ethane: Formation of indolo[2,3- c]carbazole and cyclohept[1,2-b:5,4-b']bisindole derivatives". . p. 1911 - 1916. Retrieved 2000.
• 2、 Takagi, Mio,Watanabe, Ayako,Murata, Shigeo,Takita, Ryo. "Copper-catalyzed arene amination in pure aqueous ammonia". supporting information. p. 1791 - 1795. Retrieved 2019/02/20.
• 3、 Dalvi, Bhakti A.,Lokhande, Pradeep D.. "Copper(II) catalyzed aromatization of tetrahydrocarbazole: An unprecedented protocol and its utility towards the synthesis of carbazole alkaloids". . p. 2145 - 2149. Retrieved 2018/05/08.