(2,4-Diaminopteridin-6-yl)methanol

Base Information Edit

Chemical Name:(2,4-Diaminopteridin-6-yl)methanol
CAS No.:945-24-4
Molecular Formula:C7H8N6O
Molecular Weight:192.18
Hs Code.:2933990090
European Community (EC) Number:213-412-2
UNII:1RU16O4RO0
DSSTox Substance ID:DTXSID10915479
Nikkaji Number:J298.548I
Wikidata:Q27252808
ChEMBL ID:CHEMBL78951
Mol file:945-24-4.mol

Synonyms:945-24-4;(2,4-diaminopteridin-6-yl)methanol;2,4-Diamino-6-(hydroxymethyl)pteridine;2,4-diamino-6-hydroxymethylpteridine;6-Pteridinemethanol, 2,4-diamino-;2,4-Pteridinediamine-6-methanol;2,4-Diamino-6-pteridinemethanol;(2,4-Diamino-6-pteridinyl)methanol;2,4-Diaminopteridine-6-ylmethanol;UNII-1RU16O4RO0;1RU16O4RO0;DC329;EINECS 213-412-2;6-Hydroxymethyl-2,4-pteridinediamine;SD-096950;NSC 639363;6-Pteridinemethanol, 2,4-diamino-, monohydrobromide;NSC253944;NSC 253944;EC 700-274-8;(2,4-Diaminopteridin-6-yl)methanol monohydrochloride;MFCD00006711;(2,4-Diamino-pteridin-6-yl)-methanol;Oprea1_073806;SCHEMBL64019;BIDD:GT0843;CHEMBL78951;DTXSID10915479;AMY28811;BCP09303;CS-B0318;CCG-40957;GEO-00918;NSC639363;STL372897;2,4-diamino-6-hydroxymethyl pteridine;AKOS000276916;(2,4-Diamino-6-pteridinyl)methanol #;6-(hydroxymethyl)-2,4-diaminopteridine;AS-63489;FT-0604579;METHOTREXATE IMPURITY A [EP IMPURITY];2,4-Diamino-6-(hydroxymethyl)pteridine, 95%;EN300-192043;A900133;SR-01000631064-1;W-200534;(2-amino-4-imino-3,4-dihydropteridin-6-yl)methanol;(4-Amino-2-imino-2,3-dihydropteridin-6-yl)methanol;Akos 213-118;(2,4-diamino-pteridin-6-yl)-methanol;Q27252808;Z1255386712

Suppliers and Price of (2,4-Diaminopteridin-6-yl)methanol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,4-Pteridinediamine-6-methanol
250mg
$ 155.00

TRC
2,4-Pteridinediamine-6-methanol
25mg
$ 65.00

Sigma-Aldrich
2,4-Diamino-6-(hydroxymethyl)pteridine 95%
25mg
$ 53.10

Medical Isotopes, Inc.
2,4-Pteridinediamine-6-methanol
0.5 g
$ 2000.00

Crysdot
(2,4-Diaminopteridin-6-yl)methanol 95%
25mg
$ 38.00

Crysdot
(2,4-Diaminopteridin-6-yl)methanol 95%
100mg
$ 119.00

ChemScene
(2,4-Diaminopteridin-6-yl)methanol
1g
$ 104.00

Chemenu
(2,4-Diaminopteridin-6-yl)methanol 95%+
5g
$ 88.00

Chemenu
(2,4-Diaminopteridin-6-yl)methanol 95%+
25g
$ 433.00

American Custom Chemicals Corporation
(2,4-DIAMINO-6-PTERIDINYL)METHANOL 95.00%
1G
$ 1605.45

Total 38 raw suppliers

Chemical Property of (2,4-Diaminopteridin-6-yl)methanol Edit

Chemical Property:

Appearance/Colour:Orange-Yellow Solid
Melting Point:333-334 °C (decomp)
Boiling Point:560.2 °C at 760 mmHg
PKA:12.00±0.10(Predicted)
Flash Point:292.6 °C
PSA：123.83000
Density:1.673g/cm³
LogP:0.23890
Storage Temp.:2-8°C
XLogP3:-1.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:192.07595890
Heavy Atom Count:14
Complexity:203

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Pteridinediamine-6-methanol ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=C(N=C2C(=NC(=NC2=N1)N)N)CO
Uses 2,4-Pteridinediamine-6-methanol (Methotrexate EP Impurity A) is an impurity of Methotrexate. A useful reagent for the development of selective antiparasitic compounds.

Technology Process of (2,4-Diaminopteridin-6-yl)methanol

There total 18 articles about (2,4-Diaminopteridin-6-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 73978-41-3
2,4-diamino-6-(hydroxymethyl)pteridine hydrochloride

: 945-24-4
2,4-diamino-6-(hydroxymethyl)pteridine

Guidance literature:: With ammonium hydroxide; In water; Heating;

Reference yield: 77.0%

: 191786-04-6
N-(2-Butyrylamino-6-hydroxymethyl-pteridin-4-yl)-butyramide

: 945-24-4
2,4-diamino-6-(hydroxymethyl)pteridine

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide; for 4h; Ambient temperature;
DOI:10.1002/(SICI)1099-1344(199705)39:5<363::AID-JLCR982>3.0.CO;2-O

Reference yield: 54.0%

: 96-26-4,26776-70-5
dihydroxyacetone

: 5392-28-9,49647-58-7
2,4,5,6-tetraaminopyrimidine sulfate

: 945-24-4
2,4-diamino-6-(hydroxymethyl)pteridine

Guidance literature:: 2,4,5,6-tetraaminopyrimidine sulfate; With barium(II) chloride; In water; at 100 ℃; for 0.166667h;

dihydroxyacetone; With sodium acetate; DL-cysteine hydrochloride; In water; at 20 ℃; for 24h;