3-Methoxypropylamine

Base Information

• Chemical Name: 3-Methoxypropylamine
• CAS No.: 5332-73-0
• Molecular Formula: C4H11NO
• Molecular Weight: 89.1374
• Hs Code.: 29221980
• European Community (EC) Number: 226-241-3
• NSC Number: 552
• UN Number: 2734
• UNII: VT819VO82Z
• DSSTox Substance ID: DTXSID7027596
• Nikkaji Number: J3.072D
• Wikidata: Q27292011
• ChEMBL ID: CHEMBL3186458
• Mol file: 5332-73-0.mol

Synonyms:3-methoxypropylamine;3MOPA cpd

Chemical Property of 3-Methoxypropylamine

Chemical Property:

• Appearance/Colour: clear, colorless liquid
• Vapor Pressure: 20 mm Hg ( 30 °C)
• Melting Point: -65 °C
• Refractive Index: n20/D 1.417(lit.)
• Boiling Point: 118.3 °C at 760 mmHg
• PKA: 9.73±0.10(Predicted)
• Flash Point: 22.8 °C
• PSA: 35.25000
• Density: 0.852 g/cm³
• LogP: 0.68190
• Storage Temp.: Flammables area
• Water Solubility.: miscible
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 89.084063974
• Heavy Atom Count: 6
• Complexity: 23.5

Purity/Quality:

98% ^*data from raw suppliers

3-Methoxypropylamine >99.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 10-34-35
• Safety Statements: 26-36/37/39-45-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Compounds
• Canonical SMILES: COCCCN
• Uses: Organic intermediate, emulsifier in anionic coatings and wax formulations.3-Methoxypropylamine (MOPA) is a liquid C3-Aminoether. It is used mainly as a corrosion inhibitor.

Technology Process of 3-Methoxypropylamine

There total 9 articles about 3-Methoxypropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.42%

C6H5CHNCH2CH2CH2OCH3 (105427-51-8) → 3-methoxypropylamine (5332-73-0)

Guidance literature:

C₆H₅CHNCH₂CH₂CH₂OCH₃; With hydrogenchloride; In cyclohexane; at -10 - 0 ℃; for 14h;

With sodium carbonate; In dichloromethane; at -10 - 0 ℃; for 12h;

Reference yield: 97.2%

3-Methoxypropionitrile (110-67-8) → 3-methoxypropylamine (5332-73-0)

Guidance literature:

With hydrogen; In methanol; at 105 - 110 ℃; for 0.5h; under 15001.5 - 22502.3 Torr; Temperature; Pressure; Solvent; Autoclave;

Reference yield:

3-Methoxypropionitrile (110-67-8) → bis-(3-methoxy-propyl)-amine (14676-58-5) + 3-methoxypropylamine (5332-73-0)

Guidance literature:

With ammonia; nickel; at 90 ℃; Hydrogenation_.unter Druck;

DOI:10.1021/ja01225a030

upstream raw materials:

3-Methoxypropionitrile

(3-Methoxy-propyl)-[2-methyl-prop-(Z)-ylidene]-amine

2-<(3-methoxy)propyl>-isoindole-1,3(2H)-dione

dimethyl sulfate

Downstream raw materials:

2-(3-methoxy-propylamino)-1-phenyl-ethanol

1-[4-(3-methoxy-propylsulfamoyl)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid

N-(3-methoxy-propyl)-acetamide

(3-methoxy-propyl)-(4-nitro-benzyl)-amine; hydrochloride

Refernces

• 1、 -. "Preparation method of gamma-methoxypropylamine". Paragraph 0029-0033; 0038-0042; 0047-0050; 0056-0060. . Retrieved 2019/03/28.
• 2、 Bracchi, Michael E.,Fulton, David A.. "Orthogonal breaking and forming of dynamic covalent imine and disulfide bonds in aqueous solution". supporting information. p. 11052 - 11055. Retrieved 2015/07/02.