3-Pyridazinecarboxylic acid, 6-amino-, ethyl ester

Base Information

• Chemical Name: 3-Pyridazinecarboxylic acid, 6-amino-, ethyl ester
• CAS No.: 98548-01-7
• Molecular Formula: C7H9N3O2
• Molecular Weight: 167.16500
• Hs Code.: 2933990090
• Mol file: 98548-01-7.mol

Synonyms:6-amino-pyridazine-3-carboxylic acid ethyl ester;3-Pyridazinecarboxylic acid,6-amino-,ethyl ester;6-Amino-pyridazin-3-carbonsaeure-aethylester;Ethyl6-Aminopyridazine-3-carboxylate;

Chemical Property of 3-Pyridazinecarboxylic acid, 6-amino-, ethyl ester

Chemical Property:

• PSA: 78.10000
• LogP: 0.81670
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl 6-aminopyridazine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridazinecarboxylic acid, 6-amino-, ethyl ester

There total 3 articles about 3-Pyridazinecarboxylic acid, 6-amino-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-aminopyridazine-3-carboxylic acid methyl ester (98140-96-6) + ethanol (64-17-5) → ethyl 6-aminopyridazine-3-carboxylate (98548-01-7)

Guidance literature:

ethanol; With sodium; at 20 ℃; for 2h;

methyl 6-amino-pyridazine-3-carboxylate; at 20 ℃; for 1h;

Reference yield:

C25H22N3O2P → ethyl 6-aminopyridazine-3-carboxylate (98548-01-7)

Guidance literature:

With hydrogenchloride; In dimethyl sulfoxide; at 120 ℃; for 2h;

DOI:10.1016/j.tetlet.2012.11.027

Reference yield:

6-chloro-3-pyridazinecarboxylic acid ethyl ester (75680-92-1) → ethyl 6-aminopyridazine-3-carboxylate (98548-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / dimethyl sulfoxide / 120 °C

2: hydrogenchloride / dimethyl sulfoxide / 2 h / 120 °C

With hydrogenchloride; sodium azide; In dimethyl sulfoxide; 1: |Staudinger Azide Reduction;

DOI:10.1016/j.tetlet.2012.11.027

upstream raw materials:

6-chloro-3-pyridazinecarboxylic acid ethyl ester

6-aminopyridazine-3-carboxylic acid methyl ester

ethanol

Downstream raw materials:

ethyl 2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenylimidazo[1,2-b]pyridazine-6-carboxylate

Refernces

• 1、 Kandalkar, Sachin R.,Kaduskar, Rahul D.,Ramaiah, Parimi Atchuta,Barawkar, Dinesh A.,Bhuniya, Debnath,Deshpande, Anil M.. "Highly efficient one-pot amination of carboxylate-substituted nitrogen-containing heteroaryl chlorides via Staudinger reaction". . p. 414 - 418. Retrieved 2013/02/23.