(2-Hydroxyphenyl)diphenylmethanol

Base Information

• Chemical Name: (2-Hydroxyphenyl)diphenylmethanol
• CAS No.: 6326-60-9
• Molecular Formula: C19H16 O2
• Molecular Weight: 276.335
• Hs Code.: 2907299090
• European Community (EC) Number: 667-472-3
• NSC Number: 30658
• UNII: V2XB0J02D3
• DSSTox Substance ID: DTXSID60212647
• Nikkaji Number: J1.421.755J
• Wikidata: Q83087801
• ChEMBL ID: CHEMBL117215
• Mol file: 6326-60-9.mol

Synonyms:(2-hydroxyphenyl)diphenylmethanol;6326-60-9;2-[hydroxy(diphenyl)methyl]phenol;2-hydroxytriphenylmethanol;Benzenemethanol, 2-hydroxy-alpha,alpha-diphenyl-;V2XB0J02D3;NSC-30658;2-(hydroxydiphenylmethyl)phenol;NSC30658;NSC 30658;CBMicro_014664;Cambridge id 5231306;UNII-V2XB0J02D3;CHEMBL117215;SCHEMBL2241764;O-HYDROXYTRIPHENYLCARBINOL;2-HYDROXYTRIPHENYLCARBINOL;DTXSID60212647;SMSF0005009;AKOS024335437;CB13090;BIM-0014672.P001;FT-0701980;METHANOL, (O-HYDROXYPHENYL)DIPHENYL-;AE-848/30710007;2-HYDROXY-.ALPHA.,.ALPHA.-DIPHENYLBENZENEMETHANOL;BENZENEMETHANOL, 2-HYDROXY-.ALPHA.,.ALPHA.-DIPHENYL-

Chemical Property of (2-Hydroxyphenyl)diphenylmethanol

Chemical Property:

• Vapor Pressure: 4.43E-09mmHg at 25°C
• Melting Point: 140 °C
• Boiling Point: 455.3°C at 760 mmHg
• PKA: 9.98±0.30(Predicted)
• Flash Point: 215°C
• PSA: 40.46000
• Density: 1.208g/cm³
• LogP: 3.67640
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 276.115029749
• Heavy Atom Count: 21
• Complexity: 298

Purity/Quality:

99% ^*data from raw suppliers

(2-HYDROXYPHENYL)DIPHENYLMETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3O)O

Technology Process of (2-Hydroxyphenyl)diphenylmethanol

There total 16 articles about (2-Hydroxyphenyl)diphenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2-methoxyphenyl)(diphenyl)methanol (64655-62-5) → diphenyl(2-hydroxyphenyl)methanol (6326-60-9)

Guidance literature:

With boron tribromide;

DOI:10.17159/0379-4350/2016/v69a6

Reference yield: 88.0%

phenylmagnesium bromide (100-58-3) + methyl salicylate (119-36-8,8024-54-2) → diphenyl(2-hydroxyphenyl)methanol (6326-60-9)

Guidance literature:

In tetrahydrofuran; toluene; for 12h; Reflux; Inert atmosphere;

DOI:10.1039/d0ob01868f

Reference yield: 87.0%

bromobenzene (108-86-1,52753-63-6) + methyl salicylate (119-36-8,8024-54-2) → diphenyl(2-hydroxyphenyl)methanol (6326-60-9)

Guidance literature:

With magnesium;

upstream raw materials:

phenyl Salicylate

2-hydroxy-benzoic acid ethyl ester

2-dichlorophosphoryloxy-benzoyl chloride

benzene

Downstream raw materials:

2-(3,4-dimethoxy-benzyl)-4,4-diphenyl-4H-benzo[e][1,3]oxazine

[2-(3-Dimethylamino-propoxy)-phenyl]-diphenyl-methanol

[2-(3-Diethylamino-propoxy)-phenyl]-diphenyl-methanol

4,4-diphenyl-2-propyl-4H-benzo[e][1,3]oxazine

Refernces

• 1、 Anthony, Savarimuthu Philip,Karthick, Muthupandi,Konikkara Abi, Edwin,Ramanathan, Chinnasamy Ramaraj,Someshwar, Nagamalla. "NaHSO4/SiO2catalyzed generation of: o -quinone/ o -thioquinone methides: synthesis of arylxanthenes/ arylthioxanthenes via oxa-6π-electrocyclization". supporting information. p. 8653 - 8667. Retrieved 2020/11/17.
• 2、 Govender, Thavendran,Govinden, Usha,Mocktar, Chunderika,Kruger, Hendrik G.,Veljkovi?, Jelena,Cindro, Nikola,Bobinac, Damir,?ab?i?, Ivana,Mlinari?-Majerski, Kata,Basari?, Nikola. "In vitro investigation of the antimicrobial activity of a series of lipophilic phenols and naphthols". . p. 44 - 50. Retrieved 2016/03/30.