Technology Process of Quinoline, 6-(1-methyl-1-(methylsulfonyl)ethyl)-8-(3-((1E)-2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(methylsulfonyl)phenyl)ethenyl)phenyl)-
There total 9 articles about Quinoline, 6-(1-methyl-1-(methylsulfonyl)ethyl)-8-(3-((1E)-2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(methylsulfonyl)phenyl)ethenyl)phenyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
piperidine;
In
isopropyl alcohol;
at 20 ℃;
for 22h;
Reflux;
Molecular sieve;
Large scale;
DOI:10.1021/op050116l
- Guidance literature:
-
With
sodium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
N,N-dimethyl-formamide;
at 80 ℃;
DOI:10.1016/j.bmcl.2005.08.036
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 2,2'-azobis-(2,4-dimethylvaleronitrile); N-Bromosuccinimide / chlorobenzene / 19 h / 48 - 52 °C / Inert atmosphere; Large scale
2.1: N,N-dimethyl-formamide / 3 h / 13 - 17 °C / Large scale
2.2: 1 h / 75 - 80 °C / Large scale
3.1: sodium t-butanolate / N,N-dimethyl-formamide
4.1: sodium t-butanolate / N,N-dimethyl-formamide
5.1: potassium carbonate; 5%-palladium/activated carbon / N,N-dimethyl-formamide; water / 2 h / 0.8 °C / Inert atmosphere; Large scale
6.1: piperidine / isopropyl alcohol / 22 h / 20 °C / Reflux; Molecular sieve; Large scale
With
piperidine; N-Bromosuccinimide; 2,2'-azobis-(2,4-dimethylvaleronitrile); 5%-palladium/activated carbon; potassium carbonate; sodium t-butanolate;
In
water; N,N-dimethyl-formamide; chlorobenzene; isopropyl alcohol;
5.1: |Suzuki-Miyaura Coupling / 6.1: |Knoevenagel Condensation;
DOI:10.1021/op050116l
