AP24226

Base Information

• Chemical Name: AP24226
• CAS No.: 926922-22-7
• Molecular Formula: C₂₄H₂₀F₃N₇O
• Molecular Weight: 479.464
• Mol file: 926922-22-7.mol

Synonyms:UNII-53D46B0TIH;

Chemical Property of AP24226

Chemical Property:

• PSA: 97.62000
• LogP: 5.14900

Purity/Quality:

AP-24226 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AP24226

There total 2 articles about AP24226 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-cyclopropyl-9-vinyl-9H-purin-6-amine (926922-17-0) + 3-iodo-4-methyl-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide (926922-23-8) → AP24226 (926922-22-7)

Guidance literature:

With palladium diacetate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 100 ℃; for 15h;

DOI:10.1016/j.tetlet.2007.08.008

Reference yield:

→ AP24226 (926922-22-7)

Guidance literature:

upstream raw materials:

N-cyclopropyl-9-vinyl-9H-purin-6-amine

3-iodo-4-methyl-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Refernces

• 1、 Huang, Wei-Sheng,Wang, Yihan,Sundaramoorthi, Raji,Thomas, R. Mathew,Wen, David,Liu, Shuangying,Lentini, Scott P.,Das, Sasmita,Banda, Geetha,Sawyer, Tomi K.,Shakespeare, William C.. "Facile synthesis of 9-(arenethenyl)purines via Heck reaction of 9-vinylpurines and aryl halides". . p. 7388 - 7391. Retrieved 2008/03/13.