Methyl 2-(oxetan-3-ylidene)acetate

Base Information

• Chemical Name: Methyl 2-(oxetan-3-ylidene)acetate
• CAS No.: 1105665-34-6
• Molecular Formula: C6H8O3
• Molecular Weight: 128.128
• Hs Code.: 2932990090
• Mol file: 1105665-34-6.mol

Synonyms:Acetic acid, 2-(3-oxetanylidene)-, methyl ester;Methyl oxetan-3-ylideneacetate;

Chemical Property of Methyl 2-(oxetan-3-ylidene)acetate

Chemical Property:

• Melting Point: 47-52°C
• Boiling Point: 188.241 °C at 760 mmHg
• Flash Point: 69.092 °C
• PSA: 35.53000
• Density: 1.291 g/cm³
• LogP: 0.11600
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 2-(oxetan-3-ylidene)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-(oxetan-3-ylidene)acetate

There total 2 articles about Methyl 2-(oxetan-3-ylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

oxetan-3-one (6704-31-0) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → 2-(3-oxetanylidene)acetic acid methyl ester (1105665-34-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201704119

Reference yield:

→ 2-(3-oxetanylidene)acetic acid methyl ester (1105665-34-6)

Guidance literature:

In toluene; for 2.5h; Reflux;

Reference yield: 97.0%

2-(3-oxetanylidene)acetic acid methyl ester (1105665-34-6) + C19H28N2O5S → C25H36N2O8S

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jacs.7b11793

upstream raw materials:

oxetan-3-one

methyl (triphenylphosphoranylidene)acetate

Downstream raw materials:

methyl 2-(3-aminooxetan-3-yl)acetate

Refernces

• 1、 Ellis, Bryan D.,Milligan, Jacob C.,White, Alexander R.,Duong, Vy,Altman, Pilar X.,Mohammed, Lina Y.,Crump, Matthew P.,Crosby, John,Luo, Ray,Vanderwal, Christopher D.,Tsai, Shiou-Chuan. "An Oxetane-Based Polyketide Surrogate to Probe Substrate Binding in a Polyketide Synthase". . p. 4961 - 4964. Retrieved 2018.
• 2、 -. "Furo-3-carboxamide derivatives and methods of use". Page/Page column 101; 102; 104. . Retrieved 2017/10/24.