Technology Process of 4-iodophenylacetaldehyde
There total 1 articles about 4-iodophenylacetaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
p-aminoiodobenzene;
With
hydrogenchloride;
In
water; acetone;
at 0 ℃;
for 0.0833333h;
With
sodium nitrite;
In
water; acetone;
at 0 ℃;
ethyl vinyl ether;
With
ferrocene;
In
water; acetone;
at 0 ℃;
for 0.333333h;
DOI:10.1021/jacs.0c09775
- Guidance literature:
-
With
pyrrolidine; 1,1,1,3',3',3'-hexafluoro-propanol;
at 25 ℃;
DOI:10.1021/jacs.0c09775
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium hydroxide / ethanol / 18 h / 0 - 20 °C
2: hydrazine hydrate / tetrahydrofuran / 17 h / 20 °C
3: methanol; tetrahydrofuran / 22 h / 20 °C
4: ammonium cerium (IV) nitrate / water; acetonitrile / 17 h / 20 °C
5: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 2 h / 150 °C
6: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; caesium carbonate / water; 1,4-dioxane / 15 h / 100 °C
With
ammonium cerium (IV) nitrate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; hydrazine hydrate; potassium acetate; caesium carbonate; potassium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; acetonitrile;
