Methyl 2,5-dichloroisonicotinate

Base Information

• Chemical Name: Methyl 2,5-dichloroisonicotinate
• CAS No.: 623585-74-0
• Molecular Formula: C7H5Cl2NO2
• Molecular Weight: 206.03
• Hs Code.: 2933399090
• Mol file: 623585-74-0.mol

Synonyms:methyl 2,5-dichloroisonicotinate

Chemical Property of Methyl 2,5-dichloroisonicotinate

Chemical Property:

• Vapor Pressure: 0.00515mmHg at 25°C
• Melting Point: 28-29 °C
• Refractive Index: 1.548
• Boiling Point: 275.2 °C at 760 mmHg
• Flash Point: 120.3 °C
• PSA: 39.19000
• Density: 1.426 g/cm³
• LogP: 2.17500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

Methyl2,5-dichloroisonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2,5-dichloroisonicotinate

There total 3 articles about Methyl 2,5-dichloroisonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 2,5-dichloro-4-pyridinecarboxylic acid (88912-26-9) → 2,5-dichloroisonicotinic acid methyl ester (623585-74-0)

Guidance literature:

With diazomethyl-trimethyl-silane; In dichloromethane; at 25 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2008.08.091

Reference yield: 97.0%

2,5-dichloro-4-pyridinecarboxylic acid (88912-26-9) + diazomethyl-trimethyl-silane (18107-18-1) → 2,5-dichloroisonicotinic acid methyl ester (623585-74-0)

Guidance literature:

In methanol; diethyl ether; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/chem.201703278

Reference yield:

→ 2,5-dichloroisonicotinic acid methyl ester (623585-74-0)

Guidance literature:

upstream raw materials:

methanol

2,5-dichloro-4-pyridinecarboxylic acid

diazomethyl-trimethyl-silane

Downstream raw materials:

C₁₉H₁₇N₃O

C₁₃H₁₁ClN₂O

methyl 2-(bromomethyl)-5-chloroisonicotinate

(2,5-dichloropyridin-4-yl)methanol

Refernces

• 1、 Norcott, Philip,Rayner, Peter J.,Green, Gary G. R.,Duckett, Simon B.. "Achieving High 1H Nuclear Hyperpolarization Levels with Long Lifetimes in a Range of Tuberculosis Drug Scaffolds". supporting information. p. 16990 - 16997. Retrieved 2017/11/20.
• 2、 Hanan, Emily J.,Fucini, Raymond V.,Romanowski, Michael J.,Elling, Robert A.,Lew, Willard,Purkey, Hans E.,VanderPorten, Erica C.,Yang, Wenjin. "Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors". scheme or table. p. 5186 - 5189. Retrieved 2009/05/07.