Ammonium 5-(Carbamoyl)isoxazol-3-olate

Base Information

• Chemical Name: Ammonium 5-(Carbamoyl)isoxazol-3-olate
• CAS No.: 81965-22-2
• Molecular Formula: C4H7N3O3
• Molecular Weight: 145.118
• Mol file: 81965-22-2.mol

Synonyms:3-Hydroxy-5-carbamoylisoxazole Ammonium Salt;2,3-Dihydro-3-oxo-5-isoxazolecarboxamide Ammonium Salt;

Chemical Property of Ammonium 5-(Carbamoyl)isoxazol-3-olate

Chemical Property:

• Melting Point: >206°C (dec.)
• PSA: 40.54000
• LogP: 0.41480
• Solubility.: Water

Purity/Quality:

99% ^*data from raw suppliers

Ammonium5-(Carbamoyl)isoxazol-3-olate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ammonium 5-(Carbamoyl)isoxazol-3-olate is used for preparation of cephem antibacterial agent

Technology Process of Ammonium 5-(Carbamoyl)isoxazol-3-olate

There total 1 articles about Ammonium 5-(Carbamoyl)isoxazol-3-olate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-hydroxy-5-isoxazolecarboxylate (10068-07-2) → ammonium 5-(carbamoyl)isoxazol-3-olate (81965-22-2)

Guidance literature:

With ammonium hydroxide; for 1h;

DOI:10.1002/jlac.198219820423

Reference yield:

ammonium 5-(carbamoyl)isoxazol-3-olate (81965-22-2) → muscimol hydrochloride (3579-03-1)

Guidance literature:

With hydrogenchloride; dimethylsulfide borane complex; Yield given. Multistep reaction; 1) THF, reflux, 8 h, 2) methanol, room temp. , 12 h, 3) reflux, 1 h;

DOI:10.1002/jlac.198219820423

upstream raw materials:

methyl 3-hydroxy-5-isoxazolecarboxylate

Downstream raw materials:

muscimol hydrochloride

Refernces