4-Bromomethyloxazole

Base Information

• Chemical Name: 4-Bromomethyloxazole
• CAS No.: 1065073-37-1
• Molecular Formula: C4H4BrNO
• Molecular Weight: 161.986
• Hs Code.: 2934999090
• Mol file: 1065073-37-1.mol

Synonyms:4-(Bromomethyl)-1,3-oxazole;

Chemical Property of 4-Bromomethyloxazole

Chemical Property:

• Boiling Point: 192.6 °C at 760 mmHg
• PKA: -0.73±0.12(Predicted)
• Flash Point: 70.3 °C
• PSA: 26.03000
• Density: 1.706 g/cm³
• LogP: 1.56950

Purity/Quality:

99% ^*data from raw suppliers

4-(Bromomethyl)oxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromomethyloxazole

There total 2 articles about 4-Bromomethyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxymethyl-1,3-oxazole (155742-48-6) → 4-(bromomethyl)-1,3-oxazole (1065073-37-1)

Guidance literature:

4-hydroxymethyl-1,3-oxazole; With methanesulfonyl chloride; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

With lithium bromide; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield:

methanesulfonic acid oxazol-4-ylmethyl ester (916810-52-1) → 4-(bromomethyl)-1,3-oxazole (1065073-37-1)

Guidance literature:

With lithium bromide; In DMF (N,N-dimethyl-formamide); for 1h;

Reference yield: 88.62%

4-(bromomethyl)-1,3-oxazole (1065073-37-1) + methyl-3-(4-hydroxy-3,5-diiodophenyl)-2-(methylsulfonamido)propanoate → C15H16I2N2O6S

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 5 - 20 ℃;

DOI:10.1039/c8nj04385j

upstream raw materials:

methanesulfonic acid oxazol-4-ylmethyl ester

4-hydroxymethyl-1,3-oxazole

Refernces

• 1、 -. "SUBSTITUTED OXOPYRIDINE DERIVATIVES". Paragraph 0575; 0576; 0577. . Retrieved 2017/10/27.
• 2、 -. "NOVEL ANDROGENS". Page/Page column 30. . Retrieved 2010/02/14.