4-(2-Bromoethoxy)-3-methoxybenzaldehyde

Base Information

• Chemical Name: 4-(2-Bromoethoxy)-3-methoxybenzaldehyde
• CAS No.: 99070-23-2
• Molecular Formula: C10H11BrO3
• Molecular Weight: 259.1
• Hs Code.: 2913000090
• DSSTox Substance ID: DTXSID90582087
• Wikidata: Q72455299
• Mol file: 99070-23-2.mol

Synonyms:4-(2-Bromoethoxy)-3-methoxybenzaldehyde;99070-23-2;SCHEMBL2650011;DTXSID90582087;AKOS000103475;4-(2-Bromomethoxy)-3-methoxybenzaldehyd;4-(2-bromo-ethoxy)-3-methoxy-benzaldehyde;CS-0118899;4-(2-Bromoethoxy)-3-methoxybenzaldehyde, 97%;G65739

Chemical Property of 4-(2-Bromoethoxy)-3-methoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 66-70 °C(lit.)
• Refractive Index: 1.571
• Boiling Point: 356.488
• Flash Point: 169.398°C
• PSA: 35.53000
• Density: 1.449
• LogP: 2.28140
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 257.98916
• Heavy Atom Count: 14
• Complexity: 175

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Bromoethoxy)-3-methoxybenzaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)C=O)OCCBr

Technology Process of 4-(2-Bromoethoxy)-3-methoxybenzaldehyde

There total 2 articles about 4-(2-Bromoethoxy)-3-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

vanillin (121-33-5,8014-42-4) + ethylene dibromide (106-93-4) → 4-(2-bromo-ethoxy)-3-methoxy-benzaldehyde (99070-23-2)

Guidance literature:

With sodium hydroxide; In water; at 95 ℃;

DOI:10.1080/00397910903534072

Reference yield: 79.0%

vanillin (121-33-5,8014-42-4) + ethylene dibromide (106-93-4) → 4-(2-bromo-ethoxy)-3-methoxy-benzaldehyde (99070-23-2) + 4,4′-[ethane-1,2-diylbis(oxy)]bis(3-methoxy-benzaldehyde) (5784-66-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1039/c9nj02580d

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + 4-(2-bromo-ethoxy)-3-methoxy-benzaldehyde (99070-23-2) → 3-methoxy-4-(2-morpholin-4-yl-ethoxy)benzaldehyde (46995-89-5)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux;

DOI:10.1016/j.bmcl.2016.06.077

upstream raw materials:

vanillin

ethylene dibromide

Downstream raw materials:

3-methoxy-4-[2-(piperidine-1-yl)ethoxy]-benzaldehyde

4,4′-[ethane-1,2-diylbis(oxy)]bis(3-methoxy-benzaldehyde)

4-(2-(diethylamino)ethoxy)-3-methoxybenzaldehyde

4-methylbenzenesulfonic acid [(4-formyl-2-methoxyphenoxy)ethyl] ester

Refernces

• 1、 Sava, Alexandru,Buron, Frederic,Routier, Sylvain,Panainte, Alina,Bibire, Nela,Profire, Lenu?a. "New nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold: Design, synthesis, in silico and in vitro studies". . . Retrieved 2021/05/10.
• 2、 Noureddin, Sawsan A.,El-Shishtawy, Reda M.,Al-Footy, Khalid O.. "Synthesis of new symmetric cyclic and acyclic halocurcumin analogues typical precursors for hybridization". . p. 5307 - 5323. Retrieved 2020/09/16.