3-METHYLAZETIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 3-METHYLAZETIDINE HYDROCHLORIDE
• CAS No.: 935669-28-6
• Molecular Formula: C4H10ClN
• Molecular Weight: 107.583
• Hs Code.: 2933990090
• Mol file: 935669-28-6.mol

Synonyms:-METHYLAZETIDINE BENZENESULFONATE;3-METHYLAZETIDINE BENZENESULFONIC ACID SALT;

Chemical Property of 3-METHYLAZETIDINE HYDROCHLORIDE

Chemical Property:

• PSA: 12.03000
• LogP: 1.35650
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-MethylazetidineBenzenesulfonicAcidSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYLAZETIDINE HYDROCHLORIDE

There total 4 articles about 3-METHYLAZETIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-methyl-1-tosylazetidine (35197-04-7) → 3-methylazetidinium hydrochloride (935669-28-6)

Guidance literature:

With hydrogenchloride; water; sodium; In pentan-1-ol; water; Reflux;

DOI:10.1021/jm701625v

Reference yield:

benzyl 3-methylazetidine-1-carboxylate → 3-methylazetidinium hydrochloride (935669-28-6)

Guidance literature:

benzyl 3-methylazetidine-1-carboxylate; With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; for 24h; under 3375.34 Torr;

With hydrogenchloride; In 1,4-dioxane; ethanol; at 0 ℃;

Reference yield:

benzyl 3-methyleneazetidine-1-carboxylate (934664-23-0) → 3-methylazetidinium hydrochloride (935669-28-6)

Guidance literature:

benzyl 3-methyleneazetidine-1-carboxylate; With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 40h; under 3375.34 Torr;

With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; for 24h; under 3375.34 Torr;

With hydrogenchloride; In 1,4-dioxane; ethanol; at 0 ℃;

upstream raw materials:

1-benzhydryl-3-methylene-azetidine

3-methyl-1-tosylazetidine

benzyl 3-methyleneazetidine-1-carboxylate

Downstream raw materials:

benzyl 3-methylazetidin-1-ylsulfonylcarbamate

5-((benzyloxy)methyl)-2-butyl-7-(5-(3-methylazetidin-1-yl)pent-1-yn-1-yl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine

Refernces

• 1、 -. "N- (6- ( (2R,3S) -3,4-DIHYDROXYBUTAN-2-YLOXY) -2- (4 - FLUOROBENZYLTHIO) PYRIMIDIN- 4 - YL) -3- METHYLAZETIDINE- 1 - SULFONAMIDE AS CHEMOKINE RECEPTOR MODULATOR". Page/Page column 50. . Retrieved 2013/03/26.
• 2、 Hansen, Camilla P.,Jensen, Anders A.,Christensen, Jeppe K.,Balle, Thomas,Liljefors, Tommy,Fr?lund, Bente. "Novel acetylcholine and carbamoylcholine analogues: Development of a functionally selective α4β2 nicotinic acetylcholine receptor agonist". experimental part. p. 7380 - 7395. Retrieved 2009/12/07.