3,5-Dichloro-2-nitropyridine

Base Information

• Chemical Name: 3,5-Dichloro-2-nitropyridine
• CAS No.: 610278-88-1
• Molecular Formula: C5H2Cl2N2O2
• Molecular Weight: 192.99
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50406210
• Wikidata: Q72467147
• Mol file: 610278-88-1.mol

Synonyms:3,5-dichloro-2-nitropyridine;610278-88-1;Pyridine, 3,5-dichloro-2-nitro-;SCHEMBL3545535;DTXSID50406210;ACHMQFKFXAKDAH-UHFFFAOYSA-N;Pyridine,3,5-dichloro-2-nitro-;MFCD06254585;STL227856;AKOS002664339;AC-25192;DS-16977;CS-0005560;FT-0698682;O10922;A850856

Chemical Property of 3,5-Dichloro-2-nitropyridine

Chemical Property:

• Boiling Point: 295.7±35.0 °C(Predicted)
• PKA: -5.50±0.10(Predicted)
• PSA: 58.71000
• Density: 1.629
• LogP: 2.81980
• Storage Temp.: 2-8°C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 191.9493327
• Heavy Atom Count: 11
• Complexity: 161

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5-Dichloro-2-nitropyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Cl)[N+](=O)[O-])Cl

Technology Process of 3,5-Dichloro-2-nitropyridine

There total 1 articles about 3,5-Dichloro-2-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.7%

3,5-dichloropyridin-2-amine (4214-74-8) → 3,5-dichloro-2-nitropyridine (610278-88-1)

Guidance literature:

With dipotassium peroxodisulfate; sulfuric acid; at 20 ℃;

Reference yield:

6-(4-fluoro-benzyloxy)-1,2,3,4-tetrahydro-isoquinoline + 3,5-dichloro-2-nitropyridine (610278-88-1) → C21H17ClFN3O3

Guidance literature:

With potassium carbonate; In toluene; at 60 ℃; for 10h;

DOI:10.3390/ijms21218006

Reference yield:

3,5-dichloro-2-nitropyridine (610278-88-1) + C16H16ClNO → C21H17Cl2N3O3

Guidance literature:

With potassium carbonate; In toluene; at 60 ℃; for 10h;

DOI:10.3390/ijms21218006

upstream raw materials:

3,5-dichloropyridin-2-amine

Downstream raw materials:

5-chloro-3-fluoro-2-nitropyridine

Refernces

• 1、 Illig, Carl R.,Chen, Jinsheng,Wall, Mark J.,Wilson, Kenneth J.,Ballentine, Shelley K.,Rudolph, M. Jonathan,DesJarlais, Renee L.,Chen, Yanmin,Schubert, Carsten,Petrounia, Ioanna,Crysler, Carl S.,Molloy, Christopher J.,Chaikin, Margery A.,Manthey, Carl L.,Player, Mark R.,Tomczuk, Bruce E.,Meegalla, Sanath K.. "Discovery of novel FMS kinase inhibitors as anti-inflammatory agents". . p. 1642 - 1648. Retrieved 2008/12/22.