Technology Process of 5-FLUORO-2-METHYL-3-PYRIDINECARBOXALDEHYDE
There total 4 articles about 5-FLUORO-2-METHYL-3-PYRIDINECARBOXALDEHYDE which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(5-fluoro-2-methylpyridin-3-yl) methanol;
With
4-methylmorpholine N-oxide;
In
dichloromethane;
at 20 ℃;
for 0.5h;
Molecular sieve;
With
tetrapropylammonium perruthennate;
In
dichloromethane;
at 20 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 5 h / Heating / reflux
2.1: hydrogenchloride / 1,4-dioxane / 1 h / 30 - 40 °C
2.2: pH 5.5
3.1: 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 20 °C / Molecular sieve
3.2: 1.5 h / 20 °C
With
hydrogenchloride; potassium carbonate; 4-methylmorpholine N-oxide;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: formic acid; triethylamine / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4.5 h / 90 - 100 °C
2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 5 h / Heating / reflux
3.1: hydrogenchloride / 1,4-dioxane / 1 h / 30 - 40 °C
3.2: pH 5.5
4.1: 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 20 °C / Molecular sieve
4.2: 1.5 h / 20 °C
With
hydrogenchloride; formic acid; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;