6-Benzothiazolamine, 2-bromo-

Base Information

• Chemical Name: 6-Benzothiazolamine, 2-bromo-
• CAS No.: 945400-80-6
• Molecular Formula: C₇H₅BrN₂S
• Molecular Weight: 229.1
• Hs Code.: 2934200090
• Mol file: 945400-80-6.mol

Synonyms:2-Bromo-6-benzothiazolamine;2-bromobenzo[d]thiazol-6-amine;

Chemical Property of 6-Benzothiazolamine, 2-bromo-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 384.075°C at 760 mmHg
• PKA: 2.09±0.10(Predicted)
• Flash Point: 186.082°C
• PSA: 67.15000
• Density: 1.837g/cm³
• LogP: 3.22220
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%Min ^*data from raw suppliers

2-Bromobenzo[d]thiazol-6-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Benzothiazolamine, 2-bromo-

There total 3 articles about 6-Benzothiazolamine, 2-bromo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromo-6-nitro-benzo[d]thiazole (2516-37-2) → 2-bromanyl-1,3-benzothiazol-6-amine (945400-80-6)

Guidance literature:

With sodium tetrahydridoborate; iron(II) chloride; In acetonitrile; at 26 ℃; for 14h; Inert atmosphere;

Reference yield: 58.0%

→ 2-bromanyl-1,3-benzothiazol-6-amine (945400-80-6)

Guidance literature:

With iron; acetic acid; at 20 ℃; for 16h;

Reference yield:

2-amino-6-nitrobenzothiazole (6285-57-0) → 2-bromanyl-1,3-benzothiazol-6-amine (945400-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(I) bromide; hydrogen bromide; sodium nitrite / water / 1 h / 20 °C

2: iron; ammonium chloride / water; ethanol / 100 °C / Reflux

With hydrogen bromide; iron; ammonium chloride; copper(I) bromide; sodium nitrite; In ethanol; water;

upstream raw materials:

2-bromo-6-nitro-benzo[d]thiazole

2-amino-6-nitrobenzothiazole

Refernces

• 1、 -. "NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF". Paragraph 0300-0301. . Retrieved 2021/11/04.
• 2、 -. "Derivatives with uracil-benzothiazole structure, preparation method of derivatives, and application of anti-HCV drugs". Paragraph 0045-0047. . Retrieved 2019/12/02.