Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl]

Base Information Edit

Chemical Name:Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl]
CAS No.:1100598-32-0
Molecular Formula:C29H28N6O2
Molecular Weight:492.58
Hs Code.:
Mol file:1100598-32-0.mol

Synonyms:EMD1214063;EMD 1214063;3-(1-(3-(5-((1-methylpiperidin-4-yl)methoxy)pyrimidin-2-yl)benzyl)-1,6-dihydro-6-oxopyridazin-3-yl)benzonitrile;

Suppliers and Price of Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl]

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
EMD1214063 98+%
100mg
$ 786.00

Crysdot
EMD1214063 98+%
50mg
$ 420.00

Crysdot
EMD1214063 98+%
10mg
$ 231.00

Chemenu
3-(1-(3-(5-((1-Methylpiperidin-4-yl)methoxy)pyrimidin-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile 98%
50mg
$ 258.00

Cayman Chemical
EMD 1214063 ≥98%
10mg
$ 228.00

Cayman Chemical
EMD 1214063 ≥98%
1mg
$ 35.00

Cayman Chemical
EMD 1214063 ≥98%
5mg
$ 123.00

Cayman Chemical
EMD 1214063 ≥98%
25mg
$ 481.00

Biorbyt Ltd
Tepotinib(EMD-1214063) >98%
100 mg
$ 690.20

Biorbyt Ltd
Tepotinib(EMD-1214063) >98%
1000 mg
$ 2541.50

Total 48 raw suppliers

Chemical Property of Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl] Edit

Chemical Property:

Boiling Point:626.5±65.0 °C(Predicted)
PKA:8.93±0.10(Predicted)
PSA：96.93000
Density:1.25
LogP:3.94578

Purity/Quality:

98%, ^*data from raw suppliers

EMD1214063 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Tepotinib is a highly selective inhibitor against MET. In xenograft models, acquired resistance to EGFR TKIs via secondary EGFR T790 M mutations can be overcome with tepotinib treatment.
Uses EMD 1214063 is a novel ATP-comptetitive inhibitor of the MET hepatocyte growth factor receptor and a novel kinase inhibitor and a therapeutic agent for neuroblastoma. Potent c-MET inhibitor.
Clinical Use Tepotinib is currently being evaluated in combination with EGFR TKI gefitinib and also a separate trial in NSCLC patients with MET exon 14 skipping mutation and MET amplification.
Drug interactions Tepotinib is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) who have mesenchymal-epithelial transition (_MET_) exon 14 skipping alterations.

Technology Process of Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl]

There total 2 articles about Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: