Ethyl 2-bromo-5-nitrobenzoate

Base Information

• Chemical Name: Ethyl 2-bromo-5-nitrobenzoate
• CAS No.: 208176-31-2
• Molecular Formula: C9H8BrNO4
• Molecular Weight: 274.0681
• Hs Code.: 2916399090
• Mol file: 208176-31-2.mol

Synonyms:2-Bromo-5-nitrobenzoic acid ethyl ester;Ethyl 2-bromo-5-nitrobenzoate;

Chemical Property of Ethyl 2-bromo-5-nitrobenzoate

Chemical Property:

• Vapor Pressure: 9.27E-05mmHg at 25°C
• Refractive Index: 1.576
• Boiling Point: 339.3 °C at 760 mmHg
• Flash Point: 159 °C
• PSA: 72.12000
• Density: 1.594 g/cm³
• LogP: 3.05720
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 2-bromo-5-nitrobenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-bromo-5-nitrobenzoate

There total 4 articles about Ethyl 2-bromo-5-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethanol (64-17-5) + 2-bromo-5-nitrobenzoyl chloride (80887-01-0) → 5-nitro-2-bromobenzoic acid ethyl ester (208176-31-2)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 ℃; for 24h; Reflux;

DOI:10.1021/om500315t

Reference yield:

ethanol (64-17-5) + 2-bromo-5-nitrobenzoic acid (943-14-6) → 5-nitro-2-bromobenzoic acid ethyl ester (208176-31-2)

Guidance literature:

2-bromo-5-nitrobenzoic acid; With oxalyl dichloride; In dichloromethane; at 20 ℃; for 0.5h;

ethanol; at 20 ℃; for 2h;

Reference yield:

2-bromobenzoic acid ethyl ester (6091-64-1) → 5-nitro-2-bromobenzoic acid ethyl ester (208176-31-2)

Guidance literature:

With sulfuric acid;

upstream raw materials:

ethyl iodide

2-bromobenzoic acid ethyl ester

ethanol

2-bromo-5-nitrobenzoyl chloride

Downstream raw materials:

(2-bromo-5-nitro-phenyl)methanol

2-anilino-5-nitro-benzoic acid ethyl ester

5-nitroanthranilic acid ethyl ester

Refernces

• 1、 -. "SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS". Page/Page column 66. . Retrieved 2014/10/29.