4-Chloro-N,2-dimethoxy-N-methylbenzamide

Base Information

• Chemical Name: 4-Chloro-N,2-dimethoxy-N-methylbenzamide
• CAS No.: 205320-02-1
• Molecular Formula: C10H12ClNO3
• Molecular Weight: 229.6602
• DSSTox Substance ID: DTXSID80596597
• Wikidata: Q82491896
• Mol file: 205320-02-1.mol

Synonyms:4-CHLORO-N,2-DIMETHOXY-N-METHYLBENZAMIDE;205320-02-1;4-Chloro-2,N-dimethoxy-N-methyl-benzamide;Benzamide, 4-chloro-N,2-dimethoxy-N-methyl-;SCHEMBL6333477;AMY7719;DTXSID80596597;FBQWJRHUICABKO-UHFFFAOYSA-N;AKOS006224916;4-Chloro-2,N-dimethoxy-N-methylbenzamide;CS-0336520;A847997;F1903-0226

Chemical Property of 4-Chloro-N,2-dimethoxy-N-methylbenzamide

Chemical Property:

• Boiling Point: 388 °C at 760 mmHg
• Flash Point: 188.4 °C
• PSA: 38.77000
• Density: 1.227 g/cm³
• LogP: 1.98200
• Storage Temp.: 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 229.0505709
• Heavy Atom Count: 15
• Complexity: 225

Purity/Quality:

98% purity ^*data from raw suppliers

4-Chloro-N,2-dimethoxy-N-methylbenzamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C(=O)C1=C(C=C(C=C1)Cl)OC)OC

Technology Process of 4-Chloro-N,2-dimethoxy-N-methylbenzamide

There total 2 articles about 4-Chloro-N,2-dimethoxy-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2-anisoyl chloride (5607-64-7) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 4-chloro-N,2-dimethoxy-N-methylbenzamide (205320-02-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 72h;

Reference yield:

2-methoxy-4-chlorobenzoic acid (57479-70-6) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 4-chloro-N,2-dimethoxy-N-methylbenzamide (205320-02-1)

Guidance literature:

2-methoxy-4-chlorobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 1.5h;

N,O-dimethylhydroxylamine*hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1021/jm060683e

Reference yield:

4-chloro-N,2-dimethoxy-N-methylbenzamide (205320-02-1) + ethylmagnesium bromide (925-90-6) → 4-chloro-2-methoxypropiophenone (36871-55-3)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 16h;

DOI:10.1021/jm060683e

upstream raw materials:

2-methoxy-4-chlorobenzoic acid

N,O-dimethylhydroxylamine*hydrochloride

4-chloro-2-anisoyl chloride

Downstream raw materials:

4-chloro-2-methoxypropiophenone

1-(4-chloro-2-methoxyphenyl)-ethanone

7-chloro-4-oxo-4H-chromene-2-carboxylic acid

1-(4-chloro-2-hydroxy-phenyl)-propan-1-one

Refernces

• 1、 -. "Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor". Page/Page column 21. . Retrieved 2010/02/14.