O-Acetyl N-Benzyloxycarbonyl Valganciclovir

Base Information

• Chemical Name: O-Acetyl N-Benzyloxycarbonyl Valganciclovir
• CAS No.: 194159-22-3
• Molecular Formula: C24H30N6O8
• Molecular Weight: 530.538
• Mol file: 194159-22-3.mol

Synonyms:O-Acetyl N-Benzyloxycarbonyl Valganciclovir;N-[(PhenylMethoxy)carbonyl]-L-valine 3-(Acetyloxy)-2-[(2-aMino-1,6-dihydro-6-oxo-9H-purin-9-yl)Methoxy]propyl Ester

Chemical Property of O-Acetyl N-Benzyloxycarbonyl Valganciclovir

Chemical Property:

• PKA: 9.31±0.20(Predicted)
• PSA: 194.23000
• Density: 1.42±0.1 g/cm3(Predicted)
• LogP: 1.64860

Purity/Quality:

98% ^*data from raw suppliers

O-Acetyl N-Benzyloxycarbonyl Valganciclovir ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Protected Valganciclovir, a pro-drug of ganciclovir.

Technology Process of O-Acetyl N-Benzyloxycarbonyl Valganciclovir

There total 1 articles about O-Acetyl N-Benzyloxycarbonyl Valganciclovir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-(benzyloxycarbonyl)valine (1149-26-4) + 9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine (88110-89-8) → 2-(2-amino-1,6 dihydro-6-oxo-purine-9-yl)-methoxy-3 acetoxy-1-propyl-N-(benzyloxycarbonyl)-L-valinate (194159-22-3)

Guidance literature:

(S)-N-(benzyloxycarbonyl)valine; 9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine; With dicyclohexyl-carbodiimide; In dichloromethane; for 3 - 4h;

dmap; In N,N-dimethyl-formamide; at 25 ℃; for 12h;

Reference yield:

2-(2-amino-1,6 dihydro-6-oxo-purine-9-yl)-methoxy-3 acetoxy-1-propyl-N-(benzyloxycarbonyl)-L-valinate (194159-22-3) → 2-(2-amino-1,6 dihydro-6-oxo-purine-9-yl)-methoxy-3-hydroxy-1-propyl-N-(benzyloxy carbonyl)-L-valinate (194154-40-0)

Guidance literature:

With piperidine; at 25 ℃; for 48h;

upstream raw materials:

(S)-N-(benzyloxycarbonyl)valine

9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine

Downstream raw materials:

2-(2-amino-1,6 dihydro-6-oxo-purine-9-yl)-methoxy-3-hydroxy-1-propyl-N-(benzyloxy carbonyl)-L-valinate

Refernces