5,6-DICHLORO-1H-INDAZOLE

Base Information

• Chemical Name: 5,6-DICHLORO-1H-INDAZOLE
• CAS No.: 124691-76-5
• Molecular Formula: C7H4Cl2N2
• Molecular Weight: 187.03
• Hs Code.: 2933990090
• Mol file: 124691-76-5.mol

Synonyms:NSC 38855;

Chemical Property of 5,6-DICHLORO-1H-INDAZOLE

Chemical Property:

• Melting Point: 204 °C
• Boiling Point: 347.308 °C at 760 mmHg
• PKA: 11.63±0.40(Predicted)
• Flash Point: 194.698 °C
• PSA: 28.68000
• Density: 1.572 g/cm³
• LogP: 2.86970
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

5,6-Dichloro-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-DICHLORO-1H-INDAZOLE

There total 2 articles about 5,6-DICHLORO-1H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4,5-or4,6-dichloro-2-amino-toluene (2387-08-8) → 5,6-dichloro-1H-indazole (124691-76-5)

Guidance literature:

4,5-or4,6-dichloro-2-amino-toluene; With acetic anhydride; In chloroform; at 0 - 20 ℃;

With potassium acetate; isopentyl nitrite; In chloroform; Reflux;

Reference yield:

1,2-dichloro-4-methyl-5-nitrobenzene (7494-45-3) → 5,6-dichloro-1H-indazole (124691-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium chloride; iron / tetrahydrofuran; water; methanol / 3 h / 100 °C

2.1: acetic anhydride / chloroform / 0 - 20 °C

2.2: Reflux

With acetic anhydride; iron; ammonium chloride; In tetrahydrofuran; methanol; chloroform; water;

Reference yield: 99.0%

5,6-dichloro-1H-indazole (124691-76-5) → 5,6-dichloro-3-iodo-1H-indazole (1426421-76-2)

Guidance literature:

With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 0.75h;

upstream raw materials:

4,5-or4,6-dichloro-2-amino-toluene

1,2-dichloro-4-methyl-5-nitrobenzene

Downstream raw materials:

5,6-dichloro-3-iodo-1H-indazole

5,6-dichloro-3-iodo-1-methyl-1H-indazole

Refernces

• 1、 Shimada, Itsuro,Maeno, Kyoichi,Kazuta, Ken-ichi,Kubota, Hideki,Kimizuka, Tetsuya,Kimura, Yasuharu,Hatanaka, Ken-ichi,Naitou, Yuki,Wanibuchi, Fumikazu,Sakamoto, Shuichi,Tsukamoto, Shin-ichi. "Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists". . p. 1966 - 1982. Retrieved 2008/09/21.