5,6-DIMETHOXYINDOLE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 5,6-DIMETHOXYINDOLE-2-CARBOXYLIC ACID
• CAS No.: 88210-96-2
• Molecular Formula: C11H11 N O4
• Molecular Weight: 221.213
• Hs Code.: 2933990090
• Mol file: 88210-96-2.mol

Synonyms:5,6-Dimethoxy-1H-indole-2-carboxylicacid; 5,6-Dimethoxyindole-2-carboxylic acid; 5,6-Dimethoxyindolyl-2-carboxylic acid

Chemical Property of 5,6-DIMETHOXYINDOLE-2-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 4.08E-09mmHg at 25°C
• Melting Point: 210°C (dec.)
• Boiling Point: 456.2°C at 760 mmHg
• PKA: 4.48±0.30(Predicted)
• Flash Point: 229.7°C
• PSA: 71.55000
• Density: 1.362g/cm³
• LogP: 1.88330
• Storage Temp.: 2-8°C
• Water Solubility.: Insoluble in water.

Purity/Quality:

98%min ^*data from raw suppliers

5,6-Dimethoxy-1H-indole-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5,6-Dimethoxyindole-2-carboxylic acid is used as a reagent and heterocyclic building blocks in synthetic chemistry. It is used to prepare a melanin-like polymer, poly(5,6-dimethoxyindole-2-carboxylic acid), which exhibits electrochromic properties.

Technology Process of 5,6-DIMETHOXYINDOLE-2-CARBOXYLIC ACID

There total 12 articles about 5,6-DIMETHOXYINDOLE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 5,6-dimethoxy-1H-indole-2-carboxylate (28059-24-7) → 5,6-dimethoxyindole-2-carboxylic acid (88210-96-2)

Guidance literature:

With lithium hydroxide; water; In 1,4-dioxane; at 25 ℃; for 12h;

Reference yield: 97.0%

5,6-dimethoxy-1H-indole-2-carboxylic acid ethyl ester (16382-18-6) → 5,6-dimethoxyindole-2-carboxylic acid (88210-96-2)

Guidance literature:

5,6-dimethoxy-1H-indole-2-carboxylic acid ethyl ester; With sodium hydroxide; In methanol; water; for 1h; Heating;

With hydrogenchloride; In methanol; water; at 20 ℃; for 14h;

DOI:10.1007/s12272-011-0302-1

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → 5,6-dimethoxyindole-2-carboxylic acid (88210-96-2)

Guidance literature:

With air; tyrosine ase from meal worms; water; at 26 - 30 ℃; pH 6-6,5, Reduktion der erhaltenen Loesung mit Schwefeldioxyd und Methylierung des Reaktionsprodukts mit Dimethylsulfat und Natronlauge;

upstream raw materials:

5,6-dimethoxy-1H-indole-2-carboxylic acid ethyl ester

L-tyrosine

methyl 5,6-dimethoxy-1H-indole-2-carboxylate

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

5,6-dimethoxyindole

methyl 5,6-dimethoxy-1-methyl-1H-indole-2-carboxylate

5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid

5,6-dimethoxy-2-methyl-1H-indole

Refernces

• 1、 Deng, Huayun,Fang, Ye. "Synthesis and agonistic activity at the GPR35 of 5,6-dihydroxyindole-2- carboxylic acid analogues". scheme or table. p. 550 - 554. Retrieved 2012/09/05.
• 2、 Sechi, Mario,Casu, Fabio,Campesi, Ilaria,Fiori, Stefano,Mariani, Alberto. "Hyperbranched molecular structures with potential antiviral activity: Derivatives of 5,6-dihydroxyindole-2-carboxylic acid". . p. 968 - 977. Retrieved 2007/10/03.