ethyl 3-amino-6-chloro-5-cyano-2-methylisonicotinate

Base Information

• Chemical Name: ethyl 3-amino-6-chloro-5-cyano-2-methylisonicotinate
• CAS No.: 99421-19-9
• Molecular Formula: C10H10ClN3O2
• Molecular Weight: 239.66
• Hs Code.: 2933399090
• Mol file: 99421-19-9.mol

Synonyms:3-Amino-6-chlor-5-cyan-2-methyl-isonicotinsaeure-aethylester;Ethyl 3-amino-6-chloro-5-cyano-2-methylisonicotinate;Isonicotinic acid, 3-amino-6-chloro-5-cyano-2-methyl-, ethyl ester;3-amino-6-chloro-5-cyano-2-methyl-isonicotinic acid ethyl ester;

Chemical Property of ethyl 3-amino-6-chloro-5-cyano-2-methylisonicotinate

Chemical Property:

• PSA: 89.00000
• LogP: 2.25518
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Ethyl3-amino-6-chloro-5-cyano-2-methylisonicotinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 3-amino-6-chloro-5-cyano-2-methylisonicotinate

There total 4 articles about ethyl 3-amino-6-chloro-5-cyano-2-methylisonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-cyano-2-hydroxy-6-methylisonicotinate (18619-97-1) → ethyl 3-amino-6-chloro-5-cyano-2-methylisonicotinate (99421-19-9)

Guidance literature:

Multi-step reaction with 3 steps

1: HNO₃, / acetic anhydride

2: PCl₃ / chlorobenzene

3: SnCl₂, HCl

With hydrogenchloride; nitric acid; tin(ll) chloride; phosphorus trichloride; In acetic anhydride; chlorobenzene;

DOI:10.1021/ja9632668

Reference yield:

3-cyano-2-hydroxy-6-methyl-5-nitro-isonicotinic acid ethyl ester (5427-92-9) → ethyl 3-amino-6-chloro-5-cyano-2-methylisonicotinate (99421-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₃ / chlorobenzene

2: SnCl₂, HCl

With hydrogenchloride; tin(ll) chloride; phosphorus trichloride; In chlorobenzene;

DOI:10.1021/ja9632668

Reference yield:

ethyl 2,4-diketopentanoate (615-79-2) → ethyl 3-amino-6-chloro-5-cyano-2-methylisonicotinate (99421-19-9)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₂NH

2: HNO₃, / acetic anhydride

3: PCl₃ / chlorobenzene

4: SnCl₂, HCl

With hydrogenchloride; nitric acid; diethylamine; tin(ll) chloride; phosphorus trichloride; In acetic anhydride; chlorobenzene;

DOI:10.1021/ja9632668

upstream raw materials:

2-chloro-3-cyano-6-methyl-5-nitro-isonicotinic acid ethyl ester

ethyl 3-cyano-2-hydroxy-6-methylisonicotinate

3-cyano-2-hydroxy-6-methyl-5-nitro-isonicotinic acid ethyl ester

ethyl 2,4-diketopentanoate

Downstream raw materials:

ethyl 2-methyl-3-amino-5-cyanopyridine-4-carboxylate

5-benzyloxy-6-methyl-pyridine-3,4-dicarboxylic acid dibenzyl ester

[5-(benzyloxy)-4-(hydroxymethyl)-6-methylpyridin-3-yl]methanol

4,5-bis-hydroxymethyl-3-methoxy-2-methyl-pyridine

Refernces