4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER
• CAS No.: 432022-88-3
• Molecular Formula: C10H11BrO2
• Molecular Weight: 243.1
• Mol file: 432022-88-3.mol

Synonyms:BENZOIC ACID, 4-BROMO-3,5-DIMETHYL-, METHYL ESTER;

Chemical Property of 4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.000587mmHg at 25°C
• Boiling Point: 310.8°C at 760 mmHg
• Flash Point: 141.8°C
• PSA: 26.30000
• Density: 1.38g/cm³
• LogP: 2.85250

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl4-bromo-3,5-dimethylbenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Methyl 4-Bromo-3,5-dimethylbenzoate is a useful reagent for the preparation of benzylaminopyrazinylcyclopropanecarboxylic acid derivatives for use as GPR40 receptor activity modulators.

Technology Process of 4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER

There total 4 articles about 4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methanol (67-56-1) + 4-bromo-3,5-dimethylbenzaldehyde (400822-47-1) → 4-bromo-3,5-dimethylbenzoic acid methyl ester (432022-88-3)

Guidance literature:

methanol; 4-bromo-3,5-dimethylbenzaldehyde; With potassium iodide; at 50 ℃;

With tert.-butylhydroperoxide; In methanol; for 24h; Reflux;

DOI:10.1016/j.dyepig.2018.03.054

Reference yield: 50.0%

methanol (67-56-1) + 2,4,6-trimethylphenyl bromide (576-83-0) → 4-bromo-3,5-dimethylbenzoic acid methyl ester (432022-88-3)

Guidance literature:

With tetrabutylammonium p-toluenesulfonate; at 20 ℃; for 18h; Inert atmosphere; Electrolysis; Sealed tube; Green chemistry;

DOI:10.1002/chem.202005158

Reference yield:

4-amino-3,5-dimethyl-benzoic acid methyl ester (3095-48-5) → 4-bromo-3,5-dimethylbenzoic acid methyl ester (432022-88-3)

Guidance literature:

4-amino-3,5-dimethyl-benzoic acid methyl ester; With hydrogen bromide; sodium nitrite; at 0 ℃;

With copper; Further stages.; Heating;

DOI:10.1016/j.bmcl.2007.10.063

upstream raw materials:

4-amino-3,5-dimethyl-benzoic acid methyl ester

methanol

4-bromo-3,5-dimethylbenzaldehyde

2,5-dibromo-1,3-dimethylbenzene

Downstream raw materials:

methyl 4-cyano-3,5-dimethylbenzoate

Refernces

• 1、 Song, Heli,Tang, Weiqiang,Zhao, Shuangliang,Liu, Qingyun,Xie, Yongshu. "Porphyrin sensitizers containing an auxiliary benzotriazole acceptor for dye-sensitized solar cells: Effects of steric hindrance and cosensitization". . p. 323 - 331. Retrieved 2018/04/12.