14-O-Acetyl Noroxycodone

Base Information

• Chemical Name: 14-O-Acetyl Noroxycodone
• CAS No.: 75659-91-5
• Molecular Formula: C19H21NO5
• Molecular Weight: 343.379
• Mol file: 75659-91-5.mol

Synonyms:14-O-ACETYL NOROXYCODONE;14-Acetoxy-dihydronorcodeinon;14-acetoxy-4,5α-epoxy-3-methoxy-morphinan-6-one;

Chemical Property of 14-O-Acetyl Noroxycodone

Chemical Property:

• PSA: 73.86000
• LogP: 1.60560

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 14-O-Acetyl Noroxycodone

There total 2 articles about 14-O-Acetyl Noroxycodone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + Oxycodone (76-42-6) → 14-acetoxy-7,8-dihydronorcodeinone (75659-91-5)

Guidance literature:

at 90 ℃; for 1h;

DOI:10.1124/jpet.103.058602

Reference yield:

→ 14-Acetoxy-dihydronorcodeinon (75659-91-5)

Guidance literature:

Urethan 3b;

Reference yield:

14-acetoxy-7,8-dihydronorcodeinone (75659-91-5) → noroxycodone (57664-96-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 62 percent / CHCl₃ / 24 h / Heating

2.1: H₂SO₄ / 4 h / Heating

2.2: 70 percent / aq. hydrogen iodide / ethanol

With sulfuric acid; In chloroform;

DOI:10.1124/jpet.103.058602

upstream raw materials:

acetic anhydride

Oxycodone

Downstream raw materials:

noroxycodone

14-Hydroxy-N-propylnorcodeinon

Refernces

• 1、 -. "N-dealkylation of N-alkyl-14-hydroxymorphinans and derivatives thereof". . . Retrieved 2008/06/13.