methyl 3,4-dibromobenzoate

Base Information

• Chemical Name: methyl 3,4-dibromobenzoate
• CAS No.: 51329-16-9
• Molecular Formula: C8 H6 Br2 O2
• Molecular Weight: 293.941
• Mol file: 51329-16-9.mol

Synonyms:Methyl-3,4-dibromobenzoat;benzoic acid,3,4-diamino-,methyl ester;4-carbomethoxy-o-phenylenediamine;4-methoxycarbonyl-1,2-phenylenediamine;methyl-3,4-diaminobenzoate;4-methoxycarbonyl-1,2-benzenediamine;3,4-dibromobenzoic acid methyl ester;3,4-diamino-benzoic acid methyl ester;methyl 3,4-diaminobenzenecarboxylate;

Chemical Property of methyl 3,4-dibromobenzoate

Chemical Property:

• Melting Point: 61-64 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
• Boiling Point: 318.5±22.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.840±0.06 g/cm3(Predicted)
• LogP: 2.99820

Purity/Quality:

95%+ ^*data from raw suppliers

Methyl3,4-dibromobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3,4-dibromobenzoate

There total 1 articles about methyl 3,4-dibromobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-methoxycarbonylphenyl bromide (619-42-1) → 3,4-dibromobenzoic acid methyl ester (51329-16-9)

Guidance literature:

With N-Bromosuccinimide; In sulfuric acid; ice-bath temperature -> room temperature, overnight;

DOI:10.1021/jm00128a025

Reference yield: 91.0%

3,4-dibromobenzoic acid methyl ester (51329-16-9) → 3,4-dibromobenzohydrazide

Guidance literature:

With hydrazine hydrate; In methanol; Reflux;

DOI:10.1021/acs.jmedchem.9b01004

Reference yield: 73.0%

3,4-dibromobenzoic acid methyl ester (51329-16-9) + phenylacetylene (536-74-3) → methyl 3,4-bis(2-phenylethynyl)benzoate (1351488-99-7)

Guidance literature:

3,4-dibromobenzoic acid methyl ester; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; potassium iodide; In N,N-dimethyl-formamide; Inert atmosphere;

phenylacetylene; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;

DOI:10.1002/pola.25013

upstream raw materials:

4-methoxycarbonylphenyl bromide

Downstream raw materials:

1,2-dibromo-4-(hydroxymethyl)benzene

2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester

3,4-dibromophenylacetonitrile

(S)-1-[3-(3,4-Dibromo-benzyl)-[1,2,4]oxadiazol-5-yl]-ethylamine

Refernces

• 1、 Tilley,Clader,Zawoiski,Wirkus,LeMahieu,O'Donnell,Crowley,Welton. "Biphenylcarboxamide derivatives as antagonists of platelet-activating factor". . p. 1814 - 1820. Retrieved 2007/10/02.