2-amino-6-bromo-5-methylpyrazine

Base Information

• Chemical Name: 2-amino-6-bromo-5-methylpyrazine
• CAS No.: 74290-68-9
• Molecular Formula: C5H6BrN3
• Molecular Weight: 188.027
• Hs Code.: 2933990090
• Mol file: 74290-68-9.mol

Synonyms:6-bromo-5-methylpyrazin-2-amine;

Chemical Property of 2-amino-6-bromo-5-methylpyrazine

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 154-157 °C
• Boiling Point: 290.834°C at 760 mmHg
• PKA: 1.17±0.10(Predicted)
• Flash Point: 129.692°C
• PSA: 51.80000
• Density: 1.7g/cm³
• LogP: 1.71090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

6-bromo-5-methylpyrazin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 2-Amino-6-bromo-5-methylpyrazine serves various roles in different fields. In the pharmaceutical industry, it acts as an essential intermediate in the synthesis of novel drugs and pharmaceutical compounds, contributing to the development of medications for a wide range of medical conditions. In the field of agrochemistry, this compound is used for the synthesis of crop protection agents and pesticides, playing a pivotal role in enhancing agricultural productivity and ensuring food security. Additionally, it finds applications in the realm of organic chemistry as a versatile building block, enabling the creation of diverse organic molecules with specialized properties. Its significance as a chemical building block, both in pharmaceuticals and agrochemicals, underscores its importance in these industries, facilitating advancements in healthcare and agriculture, while its role in organic chemistry widens its applicability in various scientific research and chemical processes.

Technology Process of 2-amino-6-bromo-5-methylpyrazine

There total 1 articles about 2-amino-6-bromo-5-methylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-methylpyrazin-2-amine (5521-58-4) → 2-amino-3-bromo-5-methylpyrazine (74290-65-6) + 2-amino-6-bromo-5-methylpyrazine (74290-68-9)

Guidance literature:

With pyridine; bromine; In chloroform; for 0.5h; Ambient temperature; in the dark;

Reference yield: 93.0%

2-amino-6-bromo-5-methylpyrazine (74290-68-9) + 4-methoxy-2-methylphenyl boronic acid (208399-66-0) → 6-(4-methoxy-2-methylphenyl)-5-methylpyrazin-2-amine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 130 ℃; for 2h; Inert atmosphere; Microwave irradiation;

Reference yield: 80.0%

4-[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]furo[3,2-c]pyridine (1609581-01-2) + 2-amino-6-bromo-5-methylpyrazine (74290-68-9) → 6-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-5-methylpyrazin-2-amine (1609578-15-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; ethanol; water; at 140 ℃; for 16.25h; Sealed tube; Inert atmosphere;

upstream raw materials:

5-methylpyrazin-2-amine

Downstream raw materials:

5-bromo-6-methylimidazo[1,2-a]pyrazine

6-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-5-methylpyrazin-2-amine

Refernces

• 1、 Sato, Nobuhiro. "Studies on Pyrazines. 6. A Facile Separation Method for a Mixture of the Isomeric 2-Amino-3,5, and 6-methylpyrazines". . p. 143 - 147. Retrieved 2007/10/02.